Threading Interdisciplinary Biological-Chemistry Experiments Throughout the Undergraduate Chemistry Curriculum using MALDI Mass Spectrometry

化学（12）。 该项目在整个化学课程中采用了基质辅助激光解吸/电离（MALDI）质谱法，以研究作为跨学科化学-生物学界面一部分的大生物分子。 MALDI仪器是一个新的生物分析化学课程的关键组成部分，为学生在这个化学-生物学界面的研究做好准备。 MALDI是一个重要的分析工具，在广泛的研究领域，被纳入法医学课程，一个新的介绍化学生物学综合课程，和其他几个课程。 该合并包括采用其他机构开发的实验室使用MALDI仪器，以及开发生物分析化学，仪器分析和法医科学的新实验室。 在整个课程中纳入MALDI，确保最大限度地利用仪器，同时为学生在化学或生物领域的未来研究做好准备。 学生使用MALDI的经验，他们的MALDI技术的能力和局限性的理解，并对学生学习的影响进行测量使用在线评估。 高级同行评价用于评估新的MALDI实验。 该项目演示了如何在化学课程的各个层面使用MALDI-TOF。

Chemistry (12). This project incorporates matrix-assisted laser desorption/ionization (MALDI) mass spectrometry throughout the chemistry curriculum in order to study the large bio-molecules that are part of an interdisciplinary chemistry-biology interface. The MALDI instrument is a key component in a new Bioanalytical Chemistry course that prepares students for research at this chemistry-biology interface. MALDI, an important analytical tool in a wide range of research areas, is incorporated into a Forensic Science course, a new introductory chemistry-biology integrated course, and several other courses. This incorporation includes adapting labs developed by other institutions using MALDI instrumentation as well as developing new labs for Bioanalytical Chemistry, Instrumental Analysis, and Forensic Science. The incorporation of MALDI throughout the curriculum insures maximum use of the instrument while preparing students for future research in chemical or biological fields. Students' experiences using MALDI, their understanding of the MALDI technique with its abilities and limitations, and the impact on student learning is measured using on-line evaluations. Senior peer evaluation is used to evaluate the new MALDI experiments. The project demonstrates how to use the MALDI-TOF in all levels of the chemistry curriculum.