Comparative analyses of femoral subchondral bone density in primates

灵长类动物股骨软骨下骨密度的比较分析

• 批准号: 0639630
• 负责人: John Polk
• 金额: --
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0639630&HistoricalAwards=false
• 关键词: Comparative; analyses; femoral; subchondral; bone

This project analyzes the relationships between patterns of bone density at the knee and hip joints, and locomotor function in a diverse sample of primate limb bones housed in museum collections. The project applies a methodology, the computed-tomographic measurement and spatial mapping of bone density distributions across joint surfaces, that has been experimentally validated and which can be used to identify habitual differences in joint posture and joint loading conditions in different individuals. The intellectual merits of this project are that it will analyze patterns of bone density to (1) distinguish the habitual locomotor behaviors used by particular species of primates, (2) evaluate biomechanical models for the effects of body mass on joint postures, and (3) assess levels of intraspecific variation in joint morphology. The data derived from this project will be used to interpret variation in joint loading and positional behavior in extant primates and extinct subfossil lemurs. Broader impacts include the creation of a publicly accessible database that can be used to evaluate future hypotheses of form-function relationships in primate lower extremities. Finally, this project will allow undergraduate and graduate students, including students from under-represented minorities, the opportunity to participate in research projects that investigate the relationships between bony form, locomotor function and joint loading in primates, and to contribute to the science of physical anthropology.

这个项目分析了膝关节和髋关节的骨密度模式与博物馆收藏的灵长类动物四肢骨的不同样本中的运动功能之间的关系。 该项目采用了一种方法，计算机断层扫描测量和空间映射的骨密度分布在关节表面，已被实验验证，并可用于识别习惯性差异的关节姿势和关节负荷条件在不同的个人。 该项目的智力优势在于，它将分析骨密度模式，以（1）区分特定灵长类动物使用的习惯性运动行为，（2）评估身体质量对关节姿势影响的生物力学模型，以及（3）评估关节形态的种内变异水平。 从这个项目中获得的数据将用于解释现存灵长类动物和灭绝的亚化石狐猴的关节载荷和位置行为的变化。 更广泛的影响包括创建一个可公开访问的数据库，可用于评估灵长类动物下肢形状-功能关系的未来假设。最后，该项目将使本科生和研究生，包括来自代表性不足的少数民族的学生，有机会参加研究项目，调查灵长类动物的骨骼形式，运动功能和关节负荷之间的关系，并为体质人类学做出贡献。