Functional Approaches to the Origin of the Bilaterally Symmetrical Body Plan in Animal Development

动物发育中双侧对称身体计划起源的功能方法

• 批准号: 0642273
• 负责人: Mark Martindale
• 金额: $ 39万
• 依托单位: University of Hawaii
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0642273&HistoricalAwards=false
• 关键词: Functional; Approaches; Origin; Bilaterally; Symmetrical

Mark Q. MartindaleIOB-0642273Functional approaches to the origin of the bilaterally symmetrical body plan in animal development. This proposal addresses how morphologically complex animals evolved from simpler-looking animals and the relationship between morphological and molecular complexity. Most animals display obvious features of bilateral symmetry, such as lateral appendages or eyes, however, simpler, 'radially symmetrical' animals that arose early in animal evolution do not display these features. Recent results from the Martindale lab have shown that genes that normally participate in the formation of bilaterally symmetric structures are not only present but expressed in polarized patterns in the 'radially symmetrical' anemone, Nematostella vectensis. These data indicate that 'radially symmetrical' animals are built on a bilaterally symmetrical platform that arose earlier than previously thought. Dr. Martindale proposes experiments to further investigate asymmetric gene expression in Nematostella embryos. He will take advantage of Nematostella's recently sequenced genome and his group's extensive experience in the study of Nematostella embryogenesis. He will determine when asymmetric gene expression first begins, the hierarchy of asymmetric gene activation, and the interactions between genes that leads to asymmetric gene expression. To further determine the generality of these results he proposes to study homologous gene expression in closely related stony coral embryos. Dr. Martindale has a strong track record in training graduate and postdoctoral students from diverse backgrounds and the dissemination of results and reagents to the evolution and development community.

马克·Q MartindaleIOB-0642273动物发育中双侧对称身体计划起源的功能方法。该提案解决了形态复杂的动物是如何从外观简单的动物进化而来的，以及形态和分子复杂性之间的关系。 大多数动物显示出明显的双侧对称特征，例如侧附肢或眼睛，然而，在动物进化早期出现的简单的“径向对称”动物并不显示这些特征。 马丁代尔实验室的最新研究结果表明，通常参与形成双侧对称结构的基因不仅存在，而且在“径向对称”海葵Nematostella vectensis中以极化模式表达。 这些数据表明，“径向对称”的动物是建立在一个双边对称的平台上，比以前认为的更早出现。 Martindale博士提出了进一步研究Nematostella胚胎中不对称基因表达的实验。 他将利用Nematostella最近测序的基因组和他的团队在Nematostella胚胎发生研究方面的丰富经验。 他将确定不对称基因表达何时开始，不对称基因激活的层次，以及导致不对称基因表达的基因之间的相互作用。为了进一步确定这些结果的普遍性，他建议研究密切相关的石珊瑚胚胎中的同源基因表达。 Martindale博士在培训来自不同背景的研究生和博士后学生以及向进化和发展社区传播结果和试剂方面有着良好的记录。