CAREER: Evolution of the Endomesoderm Gene Regulatory Network in Nematodes

职业：线虫内中胚层基因调控网络的进化

• 批准号: 0643325
• 负责人: Morris Maduro
• 金额: $ 70万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0643325&HistoricalAwards=false
• 关键词: CAREER; Evolution; Endomesoderm; Gene; Regulatory

Morris Ford Maduro, IOB #0643325 (CAREER)Evolution of the endomesoderm gene regulatory network in nematodesA central question in biology is - how do the different germ layers (endoderm, mesoderm and ectoderm) arise from a small number of embryonic cells that appear similar? In the last few years, the genetic pathways that determine the formation of precursors for endoderm and mesoderm have been revealed in the simple nematode, C. elegans. Dr. Maduro proposes experiments to identify factors that function to determine other tissues in C. elegans, and to examine how these pathways have changed over millions of years. He will employ a combination of molecular and genetic approaches to identify, and evaluate the function of, previously uncharacterized genes important in the early development of C. elegans. He will also perform similar experiments in the related nematode C. briggsae to investigate the evolution of the genetic pathway that specifies endoderm and mesoderm. These studies will differentiate between aspects of these pathways that are constrained in early development, and which are flexible, during evolution. As many of the regulators that function in endomesoderm development have counterparts in other animals, the results will be of broad significance. Dr. Maduro is a junior investigator of Hispanic descent and he will encourage Graduate and Undergraduate students from the ethnically diverse UC Riverside campus to participate in the work. He is a National Academies Fellow in the Life Sciences (2006-2007), and will teach and develop new pedagogy for undergraduate and graduate courses in developmental biology.

莫里斯·福特·马杜罗（Morris Ford Maduro），IOB＃0643325（职业）生物学中的Nematodesa Central问题的内胚层基因调节网络的演变是 - 不同的细菌层（内胚层，中胚层和外胚层）如何来自少量出现相似的胚胎细胞？在过去的几年中，在简单的线虫秀丽隐杆线虫C. elegans中揭示了确定内胚层和中胚层前体的遗传途径。 马杜罗（Maduro）博士提出了实验，以识别有效的因素来确定秀丽隐杆线虫中的其他组织，并检查这些途径在数百万年内如何变化。他将采用分子和遗传方法的组合来识别并评估以前未表征的基因在秀丽隐杆线虫的早期发育中重要的基因。 他还将在相关的线虫C. briggsae中进行类似的实验，以研究指定内胚层和中胚层的遗传途径的演变。这些研究将区分这些在进化过程中在早期发展中受到限制并具有灵活性的这些途径的各个方面。由于内胚层发育中功能的许多调节剂在其他动物中都具有对应物，因此结果将具有广泛的意义。 马杜罗（Maduro）博士是西班牙裔下降的初级调查员，他将鼓励来自种族多样化的UC Riverside校园的毕业生和本科生参加这项工作。他是《生命科学》（2006- 2007年）的国家科学院研究员，将教和开发新的教学法，以了解发展生物学的本科和研究生课程。