How do sensory systems interact with the hippocampus in the formation of synaptic plasticity and spatial memory? (B01)

感觉系统如何与海马体相互作用以形成突触可塑性和空间记忆？

• 批准号: 180078706
• 金额: --
• 依托单位: Abteilung für Neurophysiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/180078706?language=en
• 关键词: How; do; sensory; systems; interact

To enable the generation of a cognitive engram, the hippocampus must process multiple sensory modalities that are transferred to this structure by means of the entorhinal cortex. In the current funding period we scrutinised how olfactory information is processed by the piriform cortex (PC) and delivered to the hippocampus for subsequent encoding. Our finding that the piriform cortex resists expressing synaptic plasticity has motivated us to scrutinise the precise circuitry of the piriform cortex in the upcoming funding period. To what extent the piriform cortex can directly initiate hippocampal plasticity will also be explored. We will do this by integrating in vivo electrophysiological recordings from the hippocampus and the piriform cortex of learning rodents with optogenetics, functional in situ hybridisation and functional MRI in rodents.

为了能够产生认知记忆痕迹，海马必须处理多种感觉方式，这些感觉方式通过内嗅皮层转移到这个结构。在目前的资助期间，我们仔细研究了嗅觉信息是如何被梨状皮质（PC）处理并传递到海马体进行后续编码的。我们发现梨状皮质抵抗表达突触可塑性，这促使我们在即将到来的资助期内仔细检查梨状皮质的精确电路。梨状皮质在多大程度上可以直接启动海马可塑性也将被探索。我们将通过整合从学习啮齿动物的海马和梨状皮质的体内电生理记录与啮齿动物的光遗传学，功能性原位杂交和功能性MRI来实现这一点。