CAREER: Mechanistic Analysis of Nitrogen Oxide Chemistry under Biologically Relevant Conditions

该职业奖支持亚利桑那大学的Katrina Miranda教授在生物条件下建立NO及其单电子还原产物HNO的基本化学方面的研究。目的是阐明NO的自氧化机制，并建立HNO的基本反应机制，包括自氧化、二聚化和与NO或硫醇的结合。这些研究将阐明NO和HNO在体内的特异性反应性，并有助于确定生物学靶点。所描述的教育活动包括培训和指导各级研究生，教授生物无机化学专题课程和参与创新的多学科研究生课程。外展活动包括指导一项由美国国家科学基金会资助的亚利桑那大学REU项目，为亚利桑那社区学院系统聘用的化学教师实施一项休假计划，并指导亚利桑那州高中的学生和亚利桑那大学科学学院的新生。研究和教育活动通过向学生和主要本科院校的教育工作者提供的研究经验相结合。此外，将设立一个小组网站，为传播氮氧化物化学生物学方面的研究概念提供补充途径。

This CAREER award supports research by Professor Katrina Miranda at the University of Arizona to establish fundamental aspects of the chemistry of NO and its one electron reduction product, HNO, under biological conditions. The objectives are to elucidate the mechanisms of NO autoxidation and to establish the mechanisms of the fundamental reactivity of HNO, including autoxidation, dimerization and association with NO or thiols. Such studies will clarify the specific reactivity of NO and HNO in vivo and will contribute to identifying biological targets. The educational activities described include training and mentoring research students at all levels, teaching a special topics course on bioinorganic chemistry and participating in an innovative multidisciplinary graduate program. Outreach activities include directing an NSF-funded REU program at the University of Arizona, implementing a sabbatical program for chemistry faculty employed in the Arizona Community College system and mentoring perspective students from Arizona high schools and freshman enrolled in the UA College of Science. The research and educational activities are integrated through the research experience offered to students and to educators at primarily undergraduate institutions. Additionally, a group web site will be established to provide a supplementary avenue for dissemination of research concepts in the chemical biology of nitrogen oxides.