CAREER: Mechanistic Analysis of Nitrogen Oxide Chemistry under Biologically Relevant Conditions

职业：生物学相关条件下氮氧化物化学的机理分析

• 批准号: 0645818
• 负责人: Katrina Miranda
• 金额: $ 58.5万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645818&HistoricalAwards=false
• 关键词: CAREER; Mechanistic; Analysis; Nitrogen; Oxide

This CAREER award supports research by Professor Katrina Miranda at the University of Arizona to establish fundamental aspects of the chemistry of NO and its one electron reduction product, HNO, under biological conditions. The objectives are to elucidate the mechanisms of NO autoxidation and to establish the mechanisms of the fundamental reactivity of HNO, including autoxidation, dimerization and association with NO or thiols. Such studies will clarify the specific reactivity of NO and HNO in vivo and will contribute to identifying biological targets. The educational activities described include training and mentoring research students at all levels, teaching a special topics course on bioinorganic chemistry and participating in an innovative multidisciplinary graduate program. Outreach activities include directing an NSF-funded REU program at the University of Arizona, implementing a sabbatical program for chemistry faculty employed in the Arizona Community College system and mentoring perspective students from Arizona high schools and freshman enrolled in the UA College of Science. The research and educational activities are integrated through the research experience offered to students and to educators at primarily undergraduate institutions. Additionally, a group web site will be established to provide a supplementary avenue for dissemination of research concepts in the chemical biology of nitrogen oxides.

这个CAREER奖支持亚利桑那大学Katrina米兰达教授的研究，以建立NO及其一个电子还原产物HNO在生物条件下的化学基础。目的是阐明NO自氧化的机理，并建立HNO的基本反应性的机制，包括自氧化，二聚化和与NO或硫醇缔合。这些研究将阐明NO和HNO在体内的特异性反应性，并将有助于识别生物靶点。所描述的教育活动包括培训和指导各级研究生，讲授生物无机化学专题课程，并参加创新的多学科研究生课程。 外展活动包括指导NSF资助的REU计划在亚利桑那大学，实施休假计划在亚利桑那州社区学院系统雇用的化学教师和指导来自亚利桑那州高中的学生和大一新生就读于科学的UA学院。研究和教育活动是通过提供给学生和教育工作者在主要本科院校的研究经验相结合。此外，将建立一个小组网站，为传播氮氧化物化学生物学研究概念提供补充途径。