Upgrade of a 300 MHz NMR Spectrometer

根据化学研究仪器和设施（CRIF）项目的奖励，位于麦迪逊的威斯康星大学化学系将升级一台300 MHz核磁共振光谱仪。该设备将使研究人员能够开展以下研究：a)复杂的、具有生物活性的天然产物的合成；B)“折叠物”，低聚物表现出类似生物聚合物的离散折叠偏好；C)碳水化合物衍生物化学合成；D)茂金属催化烯烃聚合的机理研究；e)蛋白质结构-功能关系。核磁共振（NMR）波谱是化学家用来研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机化学和生物化学产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Wisconsin in Madison will upgrade a 300 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) the synthesis of complex, biologically-active natural products; b) "foldamers", oligomers that display discrete folding preferences similar to those of biopolymers; c) chemical synthesis of carbohydrate derivatives; d) mechanistic investigations of alkene polymerization as catalyzed by metallocenes; and e) protein structure-function relationships. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry.