IRES: U.S.-Poland - RNA Structures that Promote Encapsidation

IRES：美国-波兰 - 促进衣壳化的 RNA 结构

• 批准号: 0651876
• 负责人: Stefan Franzen
• 金额: --
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0651876&HistoricalAwards=false
• 关键词: IRES; U.S.; Poland; RNA; Structures

OISE 06-51876Stefan FranzenNorth Carolina State UniversityThis U.S.-Polish project is a summer undergraduate student program based at Adam Mickiewicz University (AMU) and the Institute for Bioorganic Chemistry (IBCh) of the Polish National Academy of Sciences (PAN) in Poznan, Poland. The principal investigators are Dr. Stefan Franzen at North Carolina State University, Bohdan Skalski from Adam Mickiewicz University and Ryszard Adamiak from IBCh The program involves research and education on problems of general interest for RNA structure and function. The theme of the research is the study of structures of oligonucleotides that are involved in viral coat protein assembly using methods that include modified fluorescent oligonucleotides. The PI and co-PIs have recently embarked on program of research that involves the development of novel plant viral nanotechnology. The structure of RNA is crucial for understanding viral assembly, which has application in diagnosis and prevention of virally transmitted disease as well as the new and growing area of plant viral nanotechnology. Plant viral nanotechnology involves the use of harmless plant viruses as tools for drug delivery and materials synthesis. US students will benefit from the expertise that currently exists in Poland in the area of nucleic acids chemistry.

OISE 06- 51876 Stefan Franzen北卡罗莱纳州立大学美国-波兰项目是亚当密茨凯维奇大学（AMU）和波兰国家科学院（PAN）生物有机化学研究所（IBCh）在波兹南，波兰的暑期本科生项目。 主要研究人员是北卡罗来纳州州立大学的Stefan Franzen博士，Adam Mickiewicz大学的Bohdan Skalski和IBCh的Ryszard Adamiak。该计划涉及RNA结构和功能的普遍感兴趣的问题的研究和教育。 该研究的主题是使用包括修饰的荧光寡核苷酸在内的方法研究参与病毒外壳蛋白组装的寡核苷酸的结构。PI和co-PI最近开始了一项研究计划，涉及新的植物病毒纳米技术的发展。RNA的结构对于理解病毒组装至关重要，其在病毒传播疾病的诊断和预防以及植物病毒纳米技术的新的和不断增长的领域中具有应用。 植物病毒纳米技术涉及使用无害的植物病毒作为药物输送和材料合成的工具。美国学生将受益于专业知识，目前存在于波兰在核酸化学领域。