IRES: U.S.-Poland - RNA Structures that Promote Encapsidation

OISE 06-51876Stefan Franzen北卡罗来纳州立大学该美国-波兰项目是一个暑期本科生项目，位于波兰波兹南的亚当·密茨凯维奇大学 (AMU) 和波兰国家科学院 (PAN) 生物有机化学研究所 (IBCh)。 主要研究人员包括北卡罗来纳州立大学的 Stefan Franzen 博士、Adam Mickiewicz 大学的 Bohdan Skalski 和 IBCh 的 Ryszard Adamiak。该项目涉及对 RNA 结构和功能普遍感兴趣的问题的研究和教育。 该研究的主题是使用包括修饰的荧光寡核苷酸在内的方法研究参与病毒外壳蛋白组装的寡核苷酸结构。 PI 和 co-PI 最近开始了涉及新型植物病毒纳米技术开发的研究计划。 RNA 的结构对于理解病毒组装至关重要，病毒组装可用于诊断和预防病毒传播疾病以及植物病毒纳米技术的新兴领域。 植物病毒纳米技术涉及使用无害的植物病毒作为药物输送和材料合成的工具。美国学生将受益于波兰目前在核酸化学领域的专业知识。

OISE 06-51876Stefan FranzenNorth Carolina State UniversityThis U.S.-Polish project is a summer undergraduate student program based at Adam Mickiewicz University (AMU) and the Institute for Bioorganic Chemistry (IBCh) of the Polish National Academy of Sciences (PAN) in Poznan, Poland. The principal investigators are Dr. Stefan Franzen at North Carolina State University, Bohdan Skalski from Adam Mickiewicz University and Ryszard Adamiak from IBCh The program involves research and education on problems of general interest for RNA structure and function. The theme of the research is the study of structures of oligonucleotides that are involved in viral coat protein assembly using methods that include modified fluorescent oligonucleotides. The PI and co-PIs have recently embarked on program of research that involves the development of novel plant viral nanotechnology. The structure of RNA is crucial for understanding viral assembly, which has application in diagnosis and prevention of virally transmitted disease as well as the new and growing area of plant viral nanotechnology. Plant viral nanotechnology involves the use of harmless plant viruses as tools for drug delivery and materials synthesis. US students will benefit from the expertise that currently exists in Poland in the area of nucleic acids chemistry.