IRES: U.S.-Poland - RNA Structures that Promote Encapsidation

Oise 06-51876 Stefan Franzen北卡罗来纳州立大学这个美国-波兰项目是一个夏季本科生项目，由Adam Mickiewicz大学(AMU)和波兰国家科学院(PAN)位于波兰波兹南的生物有机化学研究所(IBCH)共同完成。主要研究人员是北卡罗来纳州立大学的斯特凡·弗兰岑博士、亚当·米凯维奇大学的Bohdan Skalski和IBCH的Ryszard Adamiak。该项目涉及对RNA结构和功能普遍感兴趣的问题的研究和教育。这项研究的主题是使用包括修饰的荧光寡核苷酸在内的方法研究参与病毒外壳蛋白组装的寡核苷酸的结构。PI和共同PI最近开始了一项研究计划，涉及开发新型植物病毒纳米技术。RNA的结构对于理解病毒组装是至关重要的，它在病毒传播疾病的诊断和预防以及植物病毒纳米技术的新的和不断增长的领域中都有应用。植物病毒纳米技术包括使用无害的植物病毒作为药物输送和材料合成的工具。美国学生将受益于波兰目前在核酸化学领域的专业知识。

OISE 06-51876Stefan FranzenNorth Carolina State UniversityThis U.S.-Polish project is a summer undergraduate student program based at Adam Mickiewicz University (AMU) and the Institute for Bioorganic Chemistry (IBCh) of the Polish National Academy of Sciences (PAN) in Poznan, Poland. The principal investigators are Dr. Stefan Franzen at North Carolina State University, Bohdan Skalski from Adam Mickiewicz University and Ryszard Adamiak from IBCh The program involves research and education on problems of general interest for RNA structure and function. The theme of the research is the study of structures of oligonucleotides that are involved in viral coat protein assembly using methods that include modified fluorescent oligonucleotides. The PI and co-PIs have recently embarked on program of research that involves the development of novel plant viral nanotechnology. The structure of RNA is crucial for understanding viral assembly, which has application in diagnosis and prevention of virally transmitted disease as well as the new and growing area of plant viral nanotechnology. Plant viral nanotechnology involves the use of harmless plant viruses as tools for drug delivery and materials synthesis. US students will benefit from the expertise that currently exists in Poland in the area of nucleic acids chemistry.