Evaluation of Bisphosphonate Containing Coated Ti Foams for Osteoporosis Treatment

本研究的目标是开发表面工程双磷酸盐(BP)涂层网状钛泡沫支架，用于治疗骨丢失(如骨质疏松症)。这一目标是基于BPS在预防骨丢失方面的有效性，并作为口服BPS的替代方案，以避免副作用，同时更快地起作用。这项拟议的工作建立在泡沫钛与BP负载的CDHA的仿生涂层上，因为它通过增加骨形成成骨细胞和通过引起骨吸收破骨细胞的凋亡以双重方式帮助骨丢失的治疗。这项研究将致力于以下目标：(1)使用从研究人员获得的参数来生产无裂纹的BP负载平板基板，(2)确定涂层BP负载基板的化学特性，(3)基于结果，涂层网状泡沫钛，以及(4)进行体外测试，以检测BP负载基板和泡沫的破骨细胞和成骨细胞反应。当地和选择性地给药被视为未来医疗的一部分。因此，拟议的工作将有助于开发治疗骨质疏松症的药物植入技术。该项目将涉及代表性不足的本科生和K-12外展。

0700306BhaduriThe goal of this research is to develop surface engineered bisphoshonate (BP)-coated reticulated Ti foam scaffolds for the treatment of bone loss (such as osteoporosis). This objective is based on the effectiveness of BPs in preventing bone-loss, and as an alternative to the oral-administration of BPs to avoid side-effects while acting much more quickly. The proposed work builds upon the biomimetic coating of Ti foams with BP-loaded CDHA as it helps bone-loss treatments in a dual manner by increasing the bone-building osteoblasts and by causing apoptosis of bone-resorbing osteoclasts. This research will address the following objectives: (1) use the parameters obtained from the investigators previous research to produce crack-free BP-loaded coated flat substrates, (2) determine the chemical characteristics of the as-coated BP-loaded substrates, (3) based on the results, coat reticulated Ti foams, and (4) perform in vitro tests to examine both osteoclast and osteoblast response of the BP loaded substrates and foams. The local and selective delivery of drugs is seen as part of the future of medical treatments. Thus, the proposed work would contribute towards drug implant technology for the treatment of osteoporosis. The project will involve underrepresented undergraduate students and K-12 outreach.