Evaluation of Bisphosphonate Containing Coated Ti Foams for Osteoporosis Treatment

含双膦酸盐涂层钛泡沫治疗骨质疏松症的评价

• 批准号: 0700306
• 负责人: Sarit Bhaduri
• 金额: --
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0700306&HistoricalAwards=false
• 关键词: Evaluation; Bisphosphonate; Containing; Coated; Ti

0700306BhaduriThe goal of this research is to develop surface engineered bisphoshonate (BP)-coated reticulated Ti foam scaffolds for the treatment of bone loss (such as osteoporosis). This objective is based on the effectiveness of BPs in preventing bone-loss, and as an alternative to the oral-administration of BPs to avoid side-effects while acting much more quickly. The proposed work builds upon the biomimetic coating of Ti foams with BP-loaded CDHA as it helps bone-loss treatments in a dual manner by increasing the bone-building osteoblasts and by causing apoptosis of bone-resorbing osteoclasts. This research will address the following objectives: (1) use the parameters obtained from the investigators previous research to produce crack-free BP-loaded coated flat substrates, (2) determine the chemical characteristics of the as-coated BP-loaded substrates, (3) based on the results, coat reticulated Ti foams, and (4) perform in vitro tests to examine both osteoclast and osteoblast response of the BP loaded substrates and foams. The local and selective delivery of drugs is seen as part of the future of medical treatments. Thus, the proposed work would contribute towards drug implant technology for the treatment of osteoporosis. The project will involve underrepresented undergraduate students and K-12 outreach.

0700306 Bhaduri本研究的目的是开发表面工程化的双膦酸盐（BP）涂层网状钛泡沫支架，用于治疗骨丢失（如骨质疏松症）。这一目标是基于BP在预防骨丢失方面的有效性，并作为口服BP的替代方案，以避免副作用，同时更快地发挥作用。拟议的工作建立在钛泡沫与BP负载CDHA的仿生涂层的基础上，因为它通过增加骨构建成骨细胞和引起骨吸收破骨细胞凋亡以双重方式帮助骨丢失治疗。 这项研究将实现以下目标：（1）使用从研究者先前的研究中获得的参数来生产无裂纹的负载BP的涂覆的平坦基底，（2）确定涂覆的负载BP的基底的化学特性，（3）基于结果，涂覆网状Ti泡沫，和（4）进行体外试验以检查负载BP的基质和泡沫的破骨细胞和成骨细胞的反应。药物的局部和选择性递送被视为未来医学治疗的一部分。因此，拟议的工作将有助于药物植入技术用于治疗骨质疏松症。该项目将涉及代表性不足的本科生和K-12外展。