Alkene Insertion into Late Metal-Heteroatom Bonds

密歇根大学的John Wolfe教授在无机、生物无机和有机金属化学项目的支持下，开发了钯杂原子与烯烃的插入反应。本研究将描述促进烯烃插入Pd-N或Pd-O键的电子和几何特征。本课题研究了钯烷氧化物和钯酰胺配合物中的烯烃插入反应，为相关的催化转化提供基础。这个项目更广泛的影响包括开发新的反应序列和培养多样化的学生群体。实现烯烃在金属杂原子键上的同步插入是许多重要有机转化的关键步骤。这个跨学科的项目涉及本科生和研究生的项目，这些项目可能会影响有机合成，并应用于制药和农业产品。

Professor John Wolfe of the University of Michigan is supported by the Inorganic, Bioinorganic and Organometallic Chemistry program to develop insertion reactions of palladium heteroatoms with olefins. The electronic and geometric features that facilitate alkene insertion into Pd-N or Pd-O bonds will be delineated in this study. This research project examines alkene insertion reactions in palladium alkoxide and palladium amido complexes in order to provide a foundation for related catalytic transformations.The broader impacts of this project include the development of new reaction sequences and the training of a diverse group of students. Achieving syn insertion of olefins into late metal heteroatom bonds is a key step in numerous important organic transformations. This interdisciplinary project involves undergraduate and graduate students in projects that are likely to impact organic synthesis, with applications to both pharmaceutical and agriculture products.