Alkene Insertion into Late Metal-Heteroatom Bonds

烯烃插入后期金属杂原子键

• 批准号: 0705290
• 负责人: John Wolfe
• 金额: $ 34.2万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0705290&HistoricalAwards=false
• 关键词: Alkene; Insertion; into; Late; Metal

Professor John Wolfe of the University of Michigan is supported by the Inorganic, Bioinorganic and Organometallic Chemistry program to develop insertion reactions of palladium heteroatoms with olefins. The electronic and geometric features that facilitate alkene insertion into Pd-N or Pd-O bonds will be delineated in this study. This research project examines alkene insertion reactions in palladium alkoxide and palladium amido complexes in order to provide a foundation for related catalytic transformations.The broader impacts of this project include the development of new reaction sequences and the training of a diverse group of students. Achieving syn insertion of olefins into late metal heteroatom bonds is a key step in numerous important organic transformations. This interdisciplinary project involves undergraduate and graduate students in projects that are likely to impact organic synthesis, with applications to both pharmaceutical and agriculture products.

密歇根大学的John Wolfe教授得到了无机，生物无机和有机化学计划的支持，以开发钯杂原子与烯烃的插入反应。在本研究中，将描述促进烯烃插入Pd-N或Pd-O键的电子和几何特征。本研究计画探讨烷氧基钯与胺基钯配合物中的烯烃插入反应，为相关的催化转化提供基础。本研究计画的更广泛影响包括开发新的反应顺序，以及培养多样化的学生群体。实现烯烃到后金属杂原子键的顺式插入是许多重要有机转化中的关键步骤。这个跨学科的项目涉及本科生和研究生的项目，可能会影响有机合成，应用于制药和农业产品。