Humoral immune reconstitution after allogeneic stem cell transplantation

异体干细胞移植后体液免疫重建

• 批准号: 181828763
• 负责人: Professor Dr. Matthias Edinger
• 金额: --
• 依托单位: Klinik und Poliklinik für Innere Medizin III
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/181828763?language=en
• 关键词: Humoral; immune; reconstitution; after; allogeneic

Graft-versus-host disease (GVHD) is a major complication after allogeneic stem cell transplantation (SCT). Patients with GVHD suffer from prolonged immunodeficiency, which is usually attributed to the required immunosuppressive therapy. Using appropriate mouse models, we now aim to examine whether GVHD itself contributes to the delayed immune reconstitution. For this purpose, we examine the B cell compartment, as a coordinated interaction of all components of the adaptive immune system (T cells, B cells and antigenpresenting cells) is required for its quantitative and functional recovery. Thus, examining the reconstitution of humoral immunity permits the evaluation of the entire adoptive immune system in drug-free transplantation models. The final goal of this project is the identification of crucial cellular and molecular mechanisms causing immunodeficiency in GVHD and the development of new strategies fostering tolerance and immunity after transplantation.

移植物抗宿主病（GVHD）是异基因造血干细胞移植（SCT）后的主要并发症。患有GVHD的患者遭受长期免疫缺陷，这通常归因于所需的免疫抑制治疗。使用适当的小鼠模型，我们现在的目标是检查GVHD本身是否有助于延迟免疫重建。为此，我们研究了B细胞区室，因为适应性免疫系统的所有组分（T细胞、B细胞和抗原呈递细胞）的协调相互作用是其定量和功能恢复所必需的。因此，检查体液免疫的重建允许在无药物移植模型中评价整个过继免疫系统。该项目的最终目标是确定导致GVHD中免疫缺陷的关键细胞和分子机制，并开发促进移植后耐受和免疫的新策略。

项目成果

Dominant Th2 Differentiation of Human Regulatory T Cells upon Loss of FOXP3 Expression

• DOI: 10.4049/jimmunol.1102288
• 发表时间: 2012-02-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Hansmann, Leo;Schmidl, Christian;Edinger, Matthias
• 通讯作者: Edinger, Matthias

Altered immune reconstitution of B and T cells precedes the onset of clinical symptoms of chronic graft-versus-host disease and is influenced by the type of onset

• DOI: 10.1007/s00277-016-2881-x
• 发表时间: 2017-02-01
• 期刊: ANNALS OF HEMATOLOGY
• 影响因子: 3.5
• 作者: Bohmann, E. -M.;Fehn, U.;Wolff, D.
• 通讯作者: Wolff, D.

Total nodal irradiation in patients with severe treatment-refractory chronic graft-versus-host disease after allogeneic stem cell transplantation: Response rates and immunomodulatory effects.

异体干细胞移植后严重难治性慢性移植物抗宿主病患者的全淋巴结照射：缓解率和免疫调节作用

• DOI: 10.1016/j.radonc.2015.07.035
• 发表时间: 2015
• 期刊: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
• 作者: Hautmann AH;Wolff D;Hilgendorf I;Fehn U;Edinger M;Hoffmann P;Herr W;Kölbl O;Holler B;Sporrer D;Holler E;Hautmann MG
• 通讯作者: Hautmann MG

Langerhans cells promote early germinal center formation in response to Leishmania‐derived cutaneous antigens

朗格汉斯细胞响应利什曼原虫衍生的皮肤抗原促进早期生发中心形成

• DOI: 10.1002/eji.201344263
• 发表时间: 2014
• 期刊: European Journal of Immunology
• 影响因子: 5.4
• 作者: Zimara N;Florian C;Schmid M;Malissen B;Kissenpfennig A;Männel DN;Edinger M;Hutchinson JA;Hoffmann P;Ritter U
• 通讯作者: Ritter U

Physiologic TLR9-CpG-DNA Interaction Is Essential for the Homeostasis of the Intestinal Immune System

• DOI: 10.1097/01.mib.0000436276.19755.c1
• 发表时间: 2014-01-01
• 期刊: INFLAMMATORY BOWEL DISEASES
• 影响因子: 4.9
• 作者: Hofmann, Claudia;Dunger, Nadja;Obermeier, Florian
• 通讯作者: Obermeier, Florian