Humoral immune reconstitution after allogeneic stem cell transplantation

异体干细胞移植后体液免疫重建

• 批准号: 181828763
• 负责人: Professor Dr. Matthias Edinger
• 金额: --
• 依托单位: Klinik und Poliklinik für Innere Medizin III
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/181828763?language=en
• 关键词: Humoral; immune; reconstitution; after; allogeneic

Graft-versus-host disease (GVHD) is a major complication after allogeneic stem cell transplantation (SCT). Patients with GVHD suffer from prolonged immunodeficiency, which is usually attributed to the required immunosuppressive therapy. Using appropriate mouse models, we now aim to examine whether GVHD itself contributes to the delayed immune reconstitution. For this purpose, we examine the B cell compartment, as a coordinated interaction of all components of the adaptive immune system (T cells, B cells and antigenpresenting cells) is required for its quantitative and functional recovery. Thus, examining the reconstitution of humoral immunity permits the evaluation of the entire adoptive immune system in drug-free transplantation models. The final goal of this project is the identification of crucial cellular and molecular mechanisms causing immunodeficiency in GVHD and the development of new strategies fostering tolerance and immunity after transplantation.

在同种异体干细胞移植（SCT）后，移植物抗宿主病（GVHD）是主要的并发症。 GVHD患者患有长时间的免疫缺陷，这通常归因于所需的免疫抑制治疗。使用适当的小鼠模型，我们现在旨在检查GVHD本身是否有助于延迟的免疫重建。为此，我们检查了B细胞室，作为自适应免疫系统所有组件（T细胞，B细胞和抗原表述细胞）的协调相互作用，其定量和功能恢复。因此，检查体液免疫的重构允许在无药物移植模型中评估整个收养免疫系统。该项目的最终目标是鉴定至关重要的细胞和分子机制，导致GVHD的免疫缺陷以及发展移植后耐受性和免疫力的新策略的发展。

项目成果

Dominant Th2 Differentiation of Human Regulatory T Cells upon Loss of FOXP3 Expression

• DOI: 10.4049/jimmunol.1102288
• 发表时间: 2012-02-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Hansmann, Leo;Schmidl, Christian;Edinger, Matthias
• 通讯作者: Edinger, Matthias

Altered immune reconstitution of B and T cells precedes the onset of clinical symptoms of chronic graft-versus-host disease and is influenced by the type of onset

• DOI: 10.1007/s00277-016-2881-x
• 发表时间: 2017-02-01
• 期刊: ANNALS OF HEMATOLOGY
• 影响因子: 3.5
• 作者: Bohmann, E. -M.;Fehn, U.;Wolff, D.
• 通讯作者: Wolff, D.

Total nodal irradiation in patients with severe treatment-refractory chronic graft-versus-host disease after allogeneic stem cell transplantation: Response rates and immunomodulatory effects.

异体干细胞移植后严重难治性慢性移植物抗宿主病患者的全淋巴结照射：缓解率和免疫调节作用

• DOI: 10.1016/j.radonc.2015.07.035
• 发表时间: 2015
• 期刊: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
• 作者: Hautmann AH;Wolff D;Hilgendorf I;Fehn U;Edinger M;Hoffmann P;Herr W;Kölbl O;Holler B;Sporrer D;Holler E;Hautmann MG
• 通讯作者: Hautmann MG

Basophils inhibit proliferation of CD4+ T cells in autologous and allogeneic mixed lymphocyte reactions and limit disease activity in a murine model of graft versus host disease

• DOI: 10.1111/imm.12436
• 发表时间: 2015-06-01
• 期刊: IMMUNOLOGY
• 影响因子: 6.4
• 作者: Hermann, Fabian J.;Gomez, Manuel Rodriguez;Mack, Matthias
• 通讯作者: Mack, Matthias

Physiologic TLR9-CpG-DNA Interaction Is Essential for the Homeostasis of the Intestinal Immune System

• DOI: 10.1097/01.mib.0000436276.19755.c1
• 发表时间: 2014-01-01
• 期刊: INFLAMMATORY BOWEL DISEASES
• 影响因子: 4.9
• 作者: Hofmann, Claudia;Dunger, Nadja;Obermeier, Florian
• 通讯作者: Obermeier, Florian