U.S.-Egypt Cooperative Research: Improving Healing Performance of Wound Dressings through Formation of High Surface Area Chitosan/Cellulose Structures From Electrospun Nanofibers

0709654 Seyam描述：该项目支持北卡罗来纳州罗利市北卡罗来纳州州立大学纺织和服装技术系Abdelfattah Seyam博士的合作研究。 合作科学家是埃及开罗国家研究中心的Ahmad Waly博士。 他们计划研究如何通过静电纺丝纳米纤维形成高表面积的壳聚糖/纤维素结构来改善伤口敷料的愈合性能。智力优势：合作者将进行基础研究，以开发和评估高度可吸收的廉价壳聚糖/纤维素基结构，使用静电纺丝纳米纤维具有高表面积。主要目标是形成和评估伤口敷料的复合结构。 这些结构主要由两部分组成。第一种是基于纤维素的水凝胶材料，其能够吸收至少10倍于其重量的伤口排出液体。水凝胶纤维结构将通过用乙烯基单体接枝以赋予亲水性官能团而形成。第二种是通过从壳聚糖/纤维素溶液静电纺丝纳米纤维形成的纳米纤维的非织造层。PI将使用不同的混合比、电场、溶液浓度和加工速度从壳聚糖/纤维素纳米纤维形成一系列极薄的非织造布，并研究这些对形成的结构（纤维直径和取向、表面积和孔径）的影响。将评估水凝胶和纳米纤维非织造物的组合纤维结构的愈合性能。将在静态测试（AATCC方法100）和动态模式（ASTM E-2149-01）中评价结构对一系列细菌和酵母菌的接触杀灭性能。将监测随时间变化的细菌减少百分比（杀灭数量占总数的百分比）（改良ASTM E-2149-01）。这些测试评估了所形成的纤维结构的愈合性能/时间。愈合性能将与纳米纤维和水凝胶层的结构参数相关，以便设计伤口敷料以满足特定需求。 更广泛的影响：这项研究的结果应导致设计具有预定结构和愈合性能的伤口敷料，以满足特定需求。虽然这项研究的重点是伤口敷料，但这些研究的预期知识将有助于开发用于其他应用的廉价纤维，如医院床单，手术衣和医用手套。来自NCSU的两名博士后科学家和一名研究生将通过该项目得到部分支持。 该项目得到了美国-埃及联合基金方案的支持，该方案向两国的科学家和工程师提供赠款，以开展这些合作活动。

0709654SeyamDescription: This project supports collaborative research by Dr. Abdelfattah Seyam, Department of Textile and Apparel Technology, North Carolina State University, Raleigh, North Carolina. The collaborating scientist is Dr. Ahmad Waly, National Research Center, Cairo, Egypt. They plan to study how to improve the healing performance of wound dressing through formation of high surface area chitosan/cellulose structures from electrospun nanofibers Intellectual Merit: The collaborators will conduct fundamental research to develop and evaluate highly absorbable inexpensive chitosan/cellulose based structures with high surface area using electrospun nanofibers. The main goal is to form and evaluate composite structures for wound dressings. The structures consist mainly of two components. The first is a cellulose based hydrogelled material capable of absorbing at least 10 times of its weight of wound discharge liquids. The hydrogel fibrous structures will be formed by grafting with a vinyl monomer to impart hydrophilic functional groups. The second is a nonwoven layer of nanofibers formed by electrospinning the nanofibers from chitosan/cellulose solutions. The PIs will form a range of extremely thin nonwovens from chitosan/cellulose nanofibers using different blend ratios, electric fields, solution concentrations, and process speeds and study the impact of these on the formed structures (fiber diameter and orientation, surface area, and pore size). The combined fibrous structures of hyrogelled and nanofibers nonwoven will be evaluated for healing performance. Contact kill performance of the structures against range of bacteria and yeast in static test (AATCC Method 100) and dynamic mode (ASTM E-2149-01) will be evaluated. The percent reduction of bacteria (number killed as a percent of total number) as a function of time will be monitored (Modified ASTM E-2149-01). These tests assess healing performance/time of the developed fibrous structures. The healing performance will be correlated to the structural parameters of the nanofibers and the hydrogilled layers, in order to design wound dressings to meet specific needs. Broader Impact: The results of this research should lead to design of wound dressings with predetermined structures and healing performance to fit specific needs. While the focus of this research is on wound dressing, the expected knowledge from such research will be helpful in developing inexpensive fibers for other applications such as hospital bed sheets, surgical gowns, and medical gloves. Two post-doctoral scientists and a graduate student from NCSU will be partially supported through this project. This project is being supported under the US-Egypt Joint Fund Program, which provides grants to scientists and engineers in both countries to carry out these cooperative activities.