RUI: Development of alternative solvent extraction methods and tandem mass spectrometric analysis of polybrominated diphenyl ethers in automobile interior dust

分析和表面化学计划支持维拉诺瓦大学的Anthony Lagalante教授及其团队进行研究，以设计和测试敏感的新方法来检测和定量汽车内饰灰尘中的多溴二苯醚（PBDE）阻燃剂。 研究目标是：1）开发和推广使用环境友好的技术，利用超临界流体萃取、加压液体萃取和固相微萃取从汽车灰尘中提取多溴二苯醚; 2）开发新的灵敏度和选择性的方法，使用光喷雾-串联质谱法定量多溴联苯醚（APPI/MS/MS）和3）检查汽车变量与人体多溴二苯醚水平和降解途径的统计联系。 该项目涉及维拉诺瓦大学学生和国家标准与技术研究所分析小组科学家之间的合作努力。 学生将熟练开发先进的提取技术，并获得一系列气相色谱和液相色谱串联质谱检测的经验。 这项研究培训了维拉诺瓦大学未来的科学家，同时开发了关于多溴二苯醚的新方法和数据，这些方法和数据将对溶剂萃取、汽车设计和人类毒理学产生深远的影响。

The Analytical and Surface Chemistry Program supports Prof. Anthony Lagalante and his group at Villanova University for research to devise and test sensitive new methods to detect and quantitate polybrominated diphenyl ether (PBDE) flame retardants in automobile interior dust. The research goals are 1) to develop and promote the use of environmentally-friendly techniques for the extraction of PBDEs from automobile dust using supercritical fluid extraction, pressurized liquid extraction, and solid-phase microextraction; 2) to develop new sensitive and selective methods for PBDE quantitation using photospray-tandem mass spectrometry (APPI/MS/MS) and 3) to examine automotive variables for statistical linkages to human PBDE levels and degradation pathways. The project involves collaborative effort between Villanova University students and scientists from the Analytical Group at the National Institute of Standards and Technology. Students gain proficiency developing advanced extraction techniques and a range of experience with gas and liquid chromatography with tandem mass spectrometric detection. The research trains future scientists from Villanova University and while developing new methods and data on PBDEs that will have far-reaching consequences in solvent extraction, automotive design, and human toxicology.