GOALI: New Techniques for Solid-State NMR Studies of Pharmaceuticals

堪萨斯大学的Eric Munson教授和Revolution NMR有限责任公司的联合pi John Heinrich得到了化学部分析和表面化学项目的支持（由工程理事会的GOALI项目共同资助），以开发固态核磁共振（SSNMR）光谱的新技术，并将这些技术应用于药物感兴趣的物质。他们正在与葛兰素史克公司的研究人员合作，后者可以为制药行业的重大问题提供见解，并有助于提供有趣的化合物供研究。本研究旨在显著提高灵敏度和通量，从而扩大SSNMR在几乎所有化学领域的应用。工业合作将通过促进技术和信息的迅速传播和应用来增加价值。它们还将通过增加可分析的药物数量以及确定拟议药物制剂的潜在问题，促进安全有效的药物和药物制剂的快速发展。最后，这项工作的跨学科合作性质将加强研究生和博士后助理的教育，进行和展示这项研究。

Professor Eric Munson of the University of Kansas and co-PI John Heinrich of Revolution NMR, LLC, are supported by the Analytical and Surface Chemistry Program in the Division of Chemistry (with co-funding from the GOALI program in the Engineering Directorate) to develop new techniques for solid-state Nuclear Magnetic Resonance (SSNMR) spectroscopy, and to apply those techniques to substances of pharmaceutical interest. They are collaborating with researchers from GlaxoSmithKline, who can provide insight into significant problems in the pharmaceutical industry and can help provide interesting compounds for study. This research aims for significant increases in sensitivity and throughput that will broaden the application of SSNMR in almost all fields of chemistry. Industrial collaborations will add value by promoting the rapid dissemination and application of technologies and information. They will also promote the rapid development of safe and efficacious drugs and drug formulations by increasing the number of drugs which can be analyzed, as well as identifying potential problems with proposed drug formulations. Finally, the interdisciplinary collaborative nature of the work will enhance the education of graduate students and postdoctoral associates performing and presenting this research.