GOALI: New Techniques for Solid-State NMR Studies of Pharmaceuticals

堪萨斯大学的Eric Munson教授和革命核磁共振公司的联合PI John Heinrich，LLC得到了化学部分析和表面化学计划(工程局GOALI计划的共同资助)的支持，以开发固态核磁共振(SS核磁共振)谱的新技术，并将这些技术应用于具有制药意义的物质。他们正在与葛兰素史克的研究人员合作，这些研究人员可以洞察制药业的重大问题，并有助于提供有趣的化合物进行研究。这项研究的目的是显著提高灵敏度和吞吐量，从而扩大SS核磁共振在几乎所有化学领域的应用。产业合作将通过促进技术和信息的快速传播和应用来增加价值。它们还将通过增加可分析的药物的数量以及确定拟议药物配方的潜在问题，促进安全有效的药物和药物配方的快速发展。最后，这项工作的跨学科协作性质将加强执行和介绍这项研究的研究生和博士后助理的教育。

Professor Eric Munson of the University of Kansas and co-PI John Heinrich of Revolution NMR, LLC, are supported by the Analytical and Surface Chemistry Program in the Division of Chemistry (with co-funding from the GOALI program in the Engineering Directorate) to develop new techniques for solid-state Nuclear Magnetic Resonance (SSNMR) spectroscopy, and to apply those techniques to substances of pharmaceutical interest. They are collaborating with researchers from GlaxoSmithKline, who can provide insight into significant problems in the pharmaceutical industry and can help provide interesting compounds for study. This research aims for significant increases in sensitivity and throughput that will broaden the application of SSNMR in almost all fields of chemistry. Industrial collaborations will add value by promoting the rapid dissemination and application of technologies and information. They will also promote the rapid development of safe and efficacious drugs and drug formulations by increasing the number of drugs which can be analyzed, as well as identifying potential problems with proposed drug formulations. Finally, the interdisciplinary collaborative nature of the work will enhance the education of graduate students and postdoctoral associates performing and presenting this research.