Development of a Fourier Transform Tip - Enhanced Coherent Anti-Stokes Raman Scattering Microscope

傅里叶变换尖端的开发 - 增强型相干反斯托克斯拉曼散射显微镜

• 批准号: 0721370
• 负责人: Jennifer Ogilvie
• 金额: $ 42.18万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0721370&HistoricalAwards=false
• 关键词: Development; Fourier; Transform; Tip; Enhanced

With support from the Chemistry Research Instrumentation and Facilities Instrument Development program, Dr. Jennifer Ogilvie of the Department of Chemistry of the University of Michigan proposes to develop a Fourier transform tip-enhanced coherent anti-Stokes Raman scattering microscope (FT-TECARS). This instrument will provide chemically detailed characterization of samples, in the form of Raman spectra, with sub-diffraction-limited resolution of ~ 20 nm. The proposal aims to combine the scanning tip of an atomic force microscope to enhance the CARS signal, with a Michelson interferrometer to achieve high spectral resolution, and homodyne detection to increase discrimination against interference from far-field CARS background. The Fourier transform implementation, combined with the femtosecond laser for broad band excitation, will permit data collection over the finger print region. There are a number of research projects that could potentially benefit from such an instrument since it would allow one to gain insight into bonding and chemical properties of spatially minute surface structures. Dr. Ogilvie has decided the initial project for the FT-TECARS instrument to be the study phase behavior of model membranes composed of phospholipid/cholesterol mixtures.

在化学研究仪器和设备仪器开发计划的支持下，密歇根大学化学系的Jennifer Ogilvie博士提议开发一种傅里叶变换尖端增强相干反斯托克斯拉曼散射显微镜（FT-TECARS）。该仪器将以拉曼光谱的形式提供样品的详细化学表征，其亚衍射极限分辨率约为20 nm。 该提案旨在将原子力显微镜的扫描尖端与迈克尔逊干涉仪相结合，以增强汽车信号，实现高光谱分辨率，并通过零差检测来增加对远场汽车背景干扰的识别。傅立叶变换的实现，结合飞秒激光的宽带激发，将允许数据收集的指纹区域。有一些研究项目可能会受益于这样的仪器，因为它将允许人们深入了解空间微小表面结构的键合和化学性质。Ogilvie博士决定FT-TECARS仪器的初始项目是研究由磷脂/胆固醇混合物组成的模型膜的相行为。