Electrically Controlled Neurochemical Delivery System

电控神经化学输送系统

• 批准号: 0729869
• 负责人: Xinyan Cui
• 金额: $ 27万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0729869&HistoricalAwards=false
• 关键词: Electrically; Controlled; Neurochemical; Delivery; System

0729869CuiThe main objective of this project is to implement an electroactively controlled conductive polymer drug release device. The system will utilize the unique properties of electroactive conducting polymers, which can be synthesized by electropolymerization with ionic drug molecules incorporated, allowing for flexible drug loading onto electrodes. Upon an electrical potential change, the polymer undergoes redox reactions that lead to the release of drug from the electrodes, with the release quantity controlled by the amplitude of electrical stimulation. The specific aims of the project are: (1) in-vitro development and characterization of a conductin-based neurochemical system, and (2) in-vivo characterization of the neurochemical delivery system. The interdisciplinary research project includes elements of bioengineering, material science and neuroscience. This study will make important contributions to the field of neuro-electrode interfacing.The research will support new course development, train graduate and undergraduate students and support programs for educating women and underrepresented minorities. The results will enhance scientific understanding in multi-disciplinary fields. This project will significantly impact localized drug delivery while electrically recording the neural response in real-time.

本课题的主要目标是实现一种电活性控制的导电聚合物药物释放装置。该系统将利用电活性导电聚合物的独特特性，这种聚合物可以通过结合离子药物分子的电聚合合成，从而允许柔性药物加载到电极上。当电势发生变化时，聚合物发生氧化还原反应，导致药物从电极释放，释放量由电刺激的幅度控制。该项目的具体目标是：(1)体外开发和表征基于传导的神经化学系统，以及(2)体内表征神经化学传递系统。跨学科的研究项目包括生物工程、材料科学和神经科学的元素。这项研究将对神经电极界面领域做出重要贡献。这项研究将支持新课程开发，培训研究生和本科生，并支持教育妇女和未被充分代表的少数民族的项目。研究结果将促进多学科领域的科学理解。该项目将显著影响局部药物输送，同时实时电记录神经反应。