Computational Studies on Hemodynamics in the Microcirculation

该项目描述了使用光谱元素边界积分算法来研究微循环中三维红细胞的动力学。这项研究将回答有关不对称性的影响以及某些疾病状态对其动力学的影响的具体问题，这些疾病状态影响细胞或血浆的构成属性。研究人员将使用他们过去(在NSF的支持下)开发的斯托克斯流的高级光谱边界元算法来研究微循环中红细胞的动力学。他们将针对毛细血管中单个和多个非轴对称约束细胞的动力学，这对微循环中的运输和动力学很重要，以及疟疾和几种改变血浆粘度的疾病引起的生理变化的影响。更好地定量了解健康和疾病状态下的血细胞动力学将对健康产生明显和有益的影响。此外，PI的团队非常多样化，这个项目将使他能够继续培养一批不同的博士生。本科生将被招募到研究中，PI将把研究纳入本科生班级。

0730033DimitrakopoulosThe project describes the use a spectral-element boundary-integral algorithm to study the dynamics of three-dimensional red blood cells in the microcirculation. The research will answer specific questions about the effect of asymmetry and the effects of certain disease states, which affect the constitutive properties of the cells or the plasma, on their dynamics. The investigators will use an advanced spectral-boundary-element algorithm for Stokes flow that they have developed in the past (with NSF support) to study the dynamics of red blood cells in the microcirculation. They will target the dynamics of single and multiple non-axisymmetrically constrained cells in capillaries, which is important for transport and dynamics in the microcirculations, and the impacts of physiologic changes induced by malaria and several diseases that alter plasma viscosity. Better quantitative understanding of the dynamics of blood cells in healthy and diseased states will have obvious and beneficial impacts in health. Also, the PI's group is admirably diverse and this project will allow him to continue to train a diverse set of PhD students. The undergraduate students will be recruited into the research and the PI will incorporate the research into undergraduate classes.