Squeezing Motion of Capsules and Erythrocytes in Microfluidic Channels and Vascular Capillaries

胶囊和红细胞在狭窄的微流体通道和血管毛细血管中的挤压运动在许多生物医学和生理过程中有着广泛的应用，包括靶向给药、细胞分选和表征芯片实验室设备、血液病理学和通过毛细血管网络向体内组织输送氧气？S组织。然而，对于全三维动力学中涉及到的膜与受限固体壁界面的润滑物理问题，人们的理解是有限的。为了阐明胶囊和红细胞在狭窄的固体血管中的真实运动，该提案计划研究：(A)各种形状的方形和矩形窄微通道中的压缩运动，以及(B)直径为3-8微米的血管毛细血管中胶囊和红细胞的压缩运动。受遗传性椭圆形红细胞增多症影响的健康细胞和红细胞都将被考虑。PI和他的研究小组开发的非刚性膜光谱边界元算法将促进对这些具有挑战性的系统的计算研究。该研究可能对物理理解胶囊和红细胞在微流体通道和血管毛细血管中的真实运动做出重大贡献，从而阐明影响红细胞的靶向给药、血流阻力和细胞变形？衰老和终生。这些发现可用于改进芯片实验室设备和遗传性椭圆形红细胞增多症的控制，从而提高公众健康。该提案的结果将被整合到马里兰大学的教育项目中，并通过科学会议、期刊出版物和网络公之于众。该项目由数学科学部的数学生物学和来自化学、生物、环境和运输工程部和数学科学部的BioMaPS基金共同资助。

1335766PI: DimitrakopoulosThe squeezing motion of capsules and erythrocytes in narrow microfluidic channels and vascular capillaries has wide applications in many biomedical and physiological processes including targeted drug delivery, cell sorting and characterization lab-on-a-chip devices, hemopathology, and oxygen delivery to body?s tissues via the capillary network. However, there is limited understanding of the involved lubrication physics of membrane interfaces with the confined solid walls for the fully three-dimensional dynamics. To elucidate the realistic motion of capsules and erythrocytes in narrow solid vessels, the proposal plans to investigate: (a) the squeezing motion in narrow square and rectangular microchannels with various configurations, and (b) the squeezing motion of capsules and erythrocytes in vascular capillaries with a diameter of 3-8 microns. Both healthy cells and erythrocytes affected by hereditary elliptocytosis will be considered. The computational study of these challenging systems will be facilitated via the non-stiff Membrane Spectral Boundary Element algorithms developed by the PI and his research group.The proposed research has the potential to make a significant contribution in the physical understanding of the realistic motion of capsules and erythrocytes in microfluidic channels and vascular capillaries, and thus elucidate the targeted drug delivery, the resistance of blood flow and the cell deformation which affect the erythrocytes? aging and lifetime. These findings can be used to improve lab-on-a-chip devices and the control of hereditary elliptocytosis, and thus enhance public health. The results of the proposal will be integrated into the education program of the University of Maryland and become generally known via scientific meetings, journal publications and the web.This project is co-funded by Mathematical Biology of the Division of Mathematical Sciences and the BioMaPS fundings from the Chemical, Biological, Environmental, and Transport Division in Engineering and the Division of Mathematical Ssciences.