Squeezing Motion of Capsules and Erythrocytes in Microfluidic Channels and Vascular Capillaries

胶囊和红细胞在微流体通道和毛细血管中的挤压运动

• 批准号: 1335766
• 负责人: Panagiotis Dimitrakopoulos
• 金额: $ 30.85万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1335766&HistoricalAwards=false
• 关键词: Squeezing; Motion; Capsules; Erythrocytes; Microfluidic

1335766PI: DimitrakopoulosThe squeezing motion of capsules and erythrocytes in narrow microfluidic channels and vascular capillaries has wide applications in many biomedical and physiological processes including targeted drug delivery, cell sorting and characterization lab-on-a-chip devices, hemopathology, and oxygen delivery to body?s tissues via the capillary network. However, there is limited understanding of the involved lubrication physics of membrane interfaces with the confined solid walls for the fully three-dimensional dynamics. To elucidate the realistic motion of capsules and erythrocytes in narrow solid vessels, the proposal plans to investigate: (a) the squeezing motion in narrow square and rectangular microchannels with various configurations, and (b) the squeezing motion of capsules and erythrocytes in vascular capillaries with a diameter of 3-8 microns. Both healthy cells and erythrocytes affected by hereditary elliptocytosis will be considered. The computational study of these challenging systems will be facilitated via the non-stiff Membrane Spectral Boundary Element algorithms developed by the PI and his research group.The proposed research has the potential to make a significant contribution in the physical understanding of the realistic motion of capsules and erythrocytes in microfluidic channels and vascular capillaries, and thus elucidate the targeted drug delivery, the resistance of blood flow and the cell deformation which affect the erythrocytes? aging and lifetime. These findings can be used to improve lab-on-a-chip devices and the control of hereditary elliptocytosis, and thus enhance public health. The results of the proposal will be integrated into the education program of the University of Maryland and become generally known via scientific meetings, journal publications and the web.This project is co-funded by Mathematical Biology of the Division of Mathematical Sciences and the BioMaPS fundings from the Chemical, Biological, Environmental, and Transport Division in Engineering and the Division of Mathematical Ssciences.

1335766 PI：微囊和红细胞在狭窄微流控通道和血管毛细血管中的挤压运动在许多生物医学和生理过程中具有广泛的应用，包括靶向药物递送、细胞分选和表征芯片实验室设备、血液病理学和向身体输送氧气。s组织通过毛细血管网络。然而，有有限的了解所涉及的润滑物理膜界面与封闭的固体壁的全三维动力学。为了阐明胶囊和红细胞在狭窄固体血管中的真实运动，该提案计划研究：（a）具有各种配置的狭窄正方形和矩形微通道中的挤压运动，以及（B）直径为3-8微米的血管毛细血管中的胶囊和红细胞的挤压运动。将考虑健康细胞和受遗传性椭圆形红细胞增多症影响的红细胞。这些具有挑战性的系统的计算研究将通过PI及其研究小组开发的非刚性膜光谱边界元算法来促进。拟议的研究有可能在微流体通道和血管毛细血管中胶囊和红细胞的真实运动的物理理解方面做出重大贡献，从而阐明靶向药物递送，影响红细胞的血流阻力和细胞变形？老化和寿命。这些发现可用于改善芯片实验室设备和遗传性椭圆形红细胞增多症的控制，从而提高公众健康。该提案的结果将被纳入马里兰州的教育计划，并通过科学会议，期刊出版物和网络成为众所周知的。该项目是由数学科学部的数学生物学和BioMaPS基金共同资助的化学，生物，环境和运输工程部和数学科学部。