Nitric Oxide Transport Mechanisms: An Engineering approach

一氧化氮转运机制：一种工程方法

• 批准号: 0730547
• 负责人: Dov Jaron
• 金额: $ 27万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0730547&HistoricalAwards=false
• 关键词: Nitric; Oxide; Transport; Mechanisms; Engineering

0730547JaronThis proposal concerns the development a multi-scale approach to modeling nitric oxide production, transport and metabolism. A total of 5 objectives are stated for this proposal: (1) Expand an existing cell-scale model to include intracellular signaling and extra-cellular transport, (2) Couple a vascular-scale and cellular-scale model, (3) Develop a vascular network-scale model of NO transport, (4) Extend the model to a tissue level scale, and (5) Validate the theoretical simulations with in vitro and in vivo studies. The transport and metabolism of NO plays an important role in many normal and pathological tissue functions. As a result, this study could make important contributions to medicine and vascular physiology in general. The coupling of hemodynamics, multiple chemical reactions, and biophysical processes in an integrated multi-scale model is central to a vast number of important physiological and pathophysiological processes.The coupling of the proposed research with existing courses and other education components is a strength of this proposal. In particular, including this work in cellular biomechanics, tissue engineering, and cardiovascular engineering course work will give students an opportunity to learn some cutting edge research. The PIs have a track record of including undergraduates in their research programs. Also, multi-scale and multi-temporal methods are becoming more important in biology and physiology. As a result, this work is likely to impact a number of other areas besides NO metabolism.

0730547Jaron该提案涉及开发一种多尺度方法来模拟一氧化氮的产生、运输和代谢。本研究共提出了5个目标：（1）扩展现有的细胞尺度模型，以包括细胞内信号传导和细胞外转运，（2）耦合血管尺度和细胞尺度模型，（3）开发NO转运的血管网络尺度模型，（4）将模型扩展到组织水平，（5）将理论模拟与体外和体内研究相结合。NO的转运和代谢在许多正常和病理组织功能中起重要作用。因此，这项研究可以为医学和血管生理学做出重要贡献。在一个综合的多尺度模型中，血液动力学、多种化学反应和生物物理过程的耦合是大量重要生理和病理生理过程的核心，拟议研究与现有课程和其他教育组成部分的耦合是该提议的优势。特别是，包括在细胞生物力学，组织工程和心血管工程课程工作这项工作将让学生有机会学习一些前沿研究。PI有将本科生纳入其研究项目的记录。此外，多尺度和多时相方法在生物学和生理学中变得越来越重要。因此，这项工作可能会影响NO代谢以外的许多其他领域。