METALLOPROTEINS FOR NITRIC OXIDE TRANSPORT AND OTHER ACTIVITIES
用于一氧化氮运输和其他活动的金属蛋白
基本信息
- 批准号:7597893
- 负责人:
- 金额:$ 0.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-03-01 至 2008-02-29
- 项目状态:已结题
- 来源:
- 关键词:AffectAlpha ParticlesBedbugsBloodCarrier ProteinsComplexComputer Retrieval of Information on Scientific Projects DatabaseCopperFreezingFundingGrantHemeInsectaInstitutionMedicalMetalloproteinsMolecular ChaperonesNitric OxideOrganismProteinsResearchResearch PersonnelResolutionResourcesRhodniusScienceSignaling MoleculeSourceStructureSynchrotronsUnited States National Institutes of Healthinterestmutantprogramsresearch studysucking
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This is a program proposal for the study of five nitric oxide (NO) transport proteins called nitrophorins, and for a copper chaperone protein called CueO. NO is a ubiquitous signaling molecule in higher organisms and is of interest to medical and fundamental sciences. The nitrophorins are from two blood-sucking insects, Rhodnius prolixus (rNP1, rNP2, rNP4) and Cimex lectularius (cNP), and provide the best opportunity to date for understanding NO-heme interactions in proteins. We have crystal structures of rNP1, rNP2, and rNP4, and good crystals of cNP and CueO. The proposal is for ultrahigh resolution studies of rNP4 (to 0.8 ¿), structure determinations of NO complexes with all of the nitrophorins and their mutant forms, freeze trapping experiments with NP4, which undergoes a large conformational change in the crystal, and MAD experiments for cNP and CueO. The shorter wavelengths available at the synchrotron are required for the NO complex structure determinations, due to photodissociation or photoreduction affects that occur with Cu K-alpha radiation.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WILLIAM R. MONTFORT其他文献
WILLIAM R. MONTFORT的其他文献
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{{ truncateString('WILLIAM R. MONTFORT', 18)}}的其他基金
2011 Gordon Research Conference on Nitric Oxide
2011 年戈登一氧化氮研究会议
- 批准号:
8116107 - 财政年份:2011
- 资助金额:
$ 0.28万 - 项目类别:
Project 2: Nitric Oxide in the Tumor Micorenviroment of Triple Negative Breast Cancer
项目2:三阴性乳腺癌肿瘤微环境中的一氧化氮
- 批准号:
10473923 - 财政年份:2009
- 资助金额:
$ 0.28万 - 项目类别:
Project 2: Nitric Oxide in the Tumor Micorenviroment of Triple Negative Breast Cancer
项目2:三阴性乳腺癌肿瘤微环境中的一氧化氮
- 批准号:
10246956 - 财政年份:2009
- 资助金额:
$ 0.28万 - 项目类别:
Project 2: Nitric Oxide in the Tumor Micorenviroment of Triple Negative Breast Cancer
项目2:三阴性乳腺癌肿瘤微环境中的一氧化氮
- 批准号:
10021592 - 财政年份:2009
- 资助金额:
$ 0.28万 - 项目类别:
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