Controlling Nanoparticle Delivery in Hyperthermia for Cancer Treatment: Computational and in vivo Experimental Study

控制癌症治疗热疗中的纳米颗粒输送：计算和体内实验研究

• 批准号: 0730732
• 负责人: Ronghui Ma
• 金额: --
• 依托单位: University of Maryland Baltimore County
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0730732&HistoricalAwards=false
• 关键词: Controlling; Nanoparticle; Delivery; Hyperthermia; Cancer

CONTROLLING NANOPARTICLE DELIVERY IN HYPERTHERMIA FOR CANCER TREATMENT: COMPUTATIONAL AND IN VIVO EXPERIMENTAL STUDY Ronghui Ma and Liang ZhuCancer-related illness is the second leading cause of death in many industrialized countries. Among available therapeutic methods in cancer treatment, magnetic nanoparticle hyperthermia, in which magnetic nanoparticles delivered to tumors induce localized heating when exposed to alternating magnetic fields, is highly promising due to its simple implementation, high tumor cell-killing potential, low cost, and reduced complications. Inappropriate deposition of the particles in tumor yields unfavorable temperature distribution for cancer therapy especially when the tumor has an irregular size. Distribution of nanoparticles in biological tissue and tumor and heating patterns induced by these nanoparticles under various therapeutic conditions are not well understood. The proposal addresses the challenge of control of the dispersion of nanoparticles in the extracellular space of tumor during the administration process and development of individualized therapeutic strategy to enable optimal treatment outcome. The research effort will focus on: (1) Nanofluid transport in agarose gel; (2) In vivo experiments performed on a tumor implanted in mice to investigate the effect of tumor vasculature on the temperature elevation; and (3) Heat transfer modeling of potential scenarios of magnetic hyperthermia to design strategy of multiple injection sites in irregularly shaped tumors. The unified computational and in vivo experimental approach proposed in the study is expected to advance fundamental understanding of magnetic nanoparticle hyperthermia and enables optimal design for a heat-control algorithm and treatment protocol with improved efficacy for individualized treatment of tumors. The proposed research will be integrated into seminar series and our curricula for disseminating nano-bioscience and technology as well as educating and training students in an interdisciplinary setting. The funding will provide students from diverse backgrounds with ample research opportunities to engage in experiential training.

控制纳米颗粒在热疗中的输送用于癌症治疗：计算和体内实验研究马荣辉和梁柱癌症相关疾病是许多工业化国家的第二大死因。在现有的癌症治疗方法中，磁性纳米颗粒热疗是指将磁性纳米颗粒输送到肿瘤中，当暴露在交变磁场中时，通过局部加热来实现的，由于其实施简单，对肿瘤细胞的杀伤力高，成本低，并且减少了并发症，因此非常有前途。当肿瘤大小不规则时，肿瘤内不适当的颗粒沉积会产生不利的温度分布，尤其是当肿瘤大小不规则时。纳米粒子在生物组织和肿瘤中的分布以及这些纳米粒子在不同治疗条件下诱导的加热模式尚不清楚。该提案解决了在给药过程中控制纳米颗粒在肿瘤细胞外空间的分散以及开发个性化治疗策略以实现最佳治疗结果的挑战。研究工作将集中在：(1)纳米流体在琼脂糖凝胶中的传输；(2)在小鼠体内移植的肿瘤上进行实验，以研究肿瘤血管对温度升高的影响；以及(3)磁热治疗潜在场景的传热学模拟，以设计在不规则形状的肿瘤中多个注射部位的策略。研究中提出的统一计算和体内实验方法有望促进对磁性纳米粒子热疗的基本理解，并使热控算法和治疗方案的优化设计能够提高肿瘤个体化治疗的有效性。拟议的研究将纳入系列研讨会和我们的课程，以传播纳米生物科学和技术，并在跨学科背景下教育和培训学生。这笔资金将为来自不同背景的学生提供充足的研究机会，以从事体验式培训。