Collaborative Research: Aortic Aneurysm Pathology

合作研究：主动脉瘤病理学

• 批准号: 0733498
• 负责人: Robert Peattie
• 金额: --
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0733498&HistoricalAwards=false
• 关键词: Collaborative; Research; Aortic; Aneurysm; Pathology

Peattie0733498ABSTRACTThis project proposes a detailed investigation of the pathobiologic behavior of abdominal aortic aneurysms (AAAs). The investigators plan to construct individual phantoms of AAAs from CT scans of patients, and use the phantoms to analyze and characterize the flow patterns through the phantoms under both steady and pulsatile conditions. In the next phase of the project, arterial endothelial cells will be seeded on to the interior wall of the phantoms and allowed to multiply. Then the phantoms are tested under the specific flow and stress tests as determined earlier in the project. Finally, the cells are tested for certain selected markers which affect the arterial wall elasticity and the possibility of rupture. The project offers a balanced integration of engineering techniques, molecular biology and medicine.

Peattie0733498摘要本项目旨在详细研究腹主动脉瘤（AAA）的病理生物学行为。研究人员计划根据患者的CT扫描构建AAA的个体体模，并使用体模分析和表征在稳定和脉动条件下通过体模的流动模式。在该项目的下一阶段，动脉内皮细胞将被接种到模型的内壁上并允许繁殖。然后，在项目早期确定的特定流量和应力测试下对模型进行测试。最后，测试细胞的某些选定的影响动脉壁弹性和破裂可能性的标志物。该项目提供了工程技术，分子生物学和医学的平衡整合。