Research of the elucidation of the mechanism in the development of calcific aortic valve stenosis by shear stress

剪切应力导致钙化性主动脉瓣狭窄发生机制的阐明研究

• 批准号: 22790685
• 负责人: MIYAMOTO Takuya
• 金额: $ 2.5万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790685/
• 关键词: 大動脈弁狭窄症; 石灰化; shear stress, osteoblast, Maf B; shear stress; osteoblast; Maf B; MafB

We produced animal model of aortic stenosis (AS) by wire-injury of aortic valve of mice. Wire-injury induced significant AS and concentric cardiac hypertrophy and leaded to heart failure. We also documented the serial pathophysiological process including infiltration of inflammatory cell, phenotypic change of fibroblast to myofibroblast, and osteogenic differentiation in the injured valve tissue. This model might contribute to the understanding of pathogenesis of AS and new therapeutic strategy of AS.

采用线损伤法建立小鼠主动脉瓣狭窄(AS)模型。钢丝损伤可引起明显的AS和向心性心肌肥厚，并导致心力衰竭。我们还记录了一系列的病理生理过程，包括炎症细胞的渗透，成纤维细胞向肌成纤维细胞的表型变化，以及损伤瓣膜组织中的成骨分化。该模型可能有助于理解AS的发病机制，为AS的治疗提供新的策略。

项目成果

Prognostic Value of Low Left Atrial Appendage Wall Velocity in Patients with Ischemic Stroke and AtrialFibrillation

左心耳壁流速低对缺血性卒中合并心房颤动患者的预后价值

• DOI: 10.1016/j.echo.2012.01.012
• 发表时间: 2012
• 期刊: J Am Soc Echocardiogr
• 作者: 谷口琢也、小形岳寛;他;Harutoshi Tamura
• 通讯作者: Harutoshi Tamura

Increased Left Atrial Volume Index Predicts a Poor Prognosis in Patients With Heart Failure

• DOI: 10.1016/j.cardfail.2010.10.006
• 发表时间: 2011-03-01
• 期刊: JOURNAL OF CARDIAC FAILURE
• 影响因子: 6
• 作者: Tamura, Harutoshi;Watanabe, Tetsu;Kubota, Isao
• 通讯作者: Kubota, Isao

Device troubleshooting : cross connection of ventricular leads in a patients with decreased right ventricular electrical activity

设备故障排除：右心室电活动减少的患者的心室导线交叉连接

• DOI: 10.1093/europace/eur420
• 发表时间: 2012
• 期刊: Europace
• 影响因子: 6.1
• 作者: Kutsuzawa D;Arimoto T;Miyamoto T;Kubota I;et al
• 通讯作者: et al

Elevated cystatin C levels predict the incidence of vasospastic angina

胱抑素 C 水平升高可预测血管痉挛性心绞痛的发生率

• 发表时间: 2011
• 期刊: Circ J
• 影响因子: 3.3
• 作者: Funayama A;Watanabe T;Tamabuchi T;Otaki Y;Netsu S;Hasegawa H;Honda S;Ishino M;Arimoto T;Takahashi H;Shishido T;Miyamoto T;Nitobe J;Kubota I
• 通讯作者: Kubota I

Deficiency of the long pentraxin PTX3 deteriorates neointimal hyperplasia after vascular injury

长五聚蛋白 PTX3 的缺乏会恶化血管损伤后的新内膜增生

• 发表时间: 2011
• 作者: Ishino M;Shishido T;Suzuki S;Katoh S;Sasaki T;Netsu S;Funayama A;Arimoto T;Nishiyama S;Takahashi H;Miyashita T;Miyamoto T;Watanabe T;Takeishi Y;Kubota I
• 通讯作者: Kubota I