Using cell lines as a model for stem cell biology in an undergraduate environment

生物科学（61）智力优势：使用易于获得的细胞系（如PC 12和L 6），可以在受控条件下体外分化，该项目正在开发一个综合的经验，在本科细胞生物学实验室，模型研究干细胞生物学。具体而言，该项目是：（1）通过在受影响的细胞生物学课程中开展以学生为中心的主动学习活动，提高学生的科学理解水平;（2）扩大学生在细胞生物学领域完成独立的师生实验室研究的机会;（3）开发可供他人使用的学生和教师讲座和实验室手册。该项目适应细胞生物学的方法下开发的先前的NSF补助金（9950735），成功地提高了培训，理解和研究机会，为学生在神经科学。除了与课程相关的培训，并从它的一个副产品，学生正在成为参与独立的实证实验室研究项目，在地方和国家会议上展示他们的结果，并在提交同行评审的科学期刊作为合著者作出贡献。更广泛的影响：该项目解决了生命科学本科教育的一个重要目标，挑战学生作为科学家思考，而不是作为大学内外的技术人员。详细的学生和教师手册提供了一个易于遵循的计划，向学生介绍科学和技术在社会中的作用，细胞生物学，干细胞技术和实验研究，通过在课堂和实验室环境中的协作学习活动的主题。阿卡迪亚大学参加了TRIO/McNair合作计划，以招募和鼓励来自代表性不足群体的学生为高级研究生课程做准备。生物学教师目前参与提供科学内容，学生在阿卡迪亚大学的教师教育计划，研讨会继续教育目前K12教师，教师发展为科学教师在当地大学。 该项目有助于推动这项工作。

Biological Sciences (61)Intellectual Merit: Using readily-accessible cell lines (such as PC12 and L6) that can be differentiated in vitro under controlled conditions, this project is developing an integrated experience in undergraduate cell biology laboratories that models research in stem cell biology. Specifically, this project is: (1) improving the level of scientific comprehension of students by developing student-centered active learning activities within the affected cell biology course; (2) expanding opportunities for students to complete independent faculty-student laboratory research in the field of cell biology; and (3) developing student and instructor lecture and laboratory manuals that can be used by others. This project adapts for cell biology the approach developed under a previous NSF grant (9950735) that successfully enhanced training, comprehension, and research opportunities for students in the neurosciences. In addition to the course-related training and as an outgrowth from it, students are becoming involved in independent empirical laboratory research projects, presenting their results at local and national meetings, and contributing as co-authors in submissions to peer-reviewed scientific journals. Broader Impact: This project addresses an important goal in undergraduate education in the life sciences, to challenge students to think as scientists, rather than as technicians both within and outside of the university. The detailed student and instructor manuals provide an easy-to-follow plan for presenting students with topics on the role of science and technology in society, cell biology, stem cell technology, and experimental research through collaborative learning activities in both the classroom and the laboratory setting. Arcadia University participates in a TRIO/McNair Partnership Program to recruit and encourage students from underrepresented groups to prepare for advanced graduate studies. Biology faculty members are currently involved in providing scientific content to students in Arcadia University's teacher education programs, workshops for continuing education of current K12 teachers, and faculty development for science faculty at local universities. This project helps to advance that work.