STTR Phase I: Intraventricular Cooling Catheter

STTR 第一期：脑室内冷却导管

• 批准号: 0740266
• 负责人: John Elefteriades
• 金额: $ 14.09万
• 依托单位: CoolSpine LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0740266&HistoricalAwards=false
• 关键词: STTR; Phase; Intraventricular; Cooling; Catheter

This Small Business Technology Transfer (STTR) Phase I research project aims to develop a catheter for cooling the brain tissue of individuals who have suffered from traumatic brain injury (TBI). The catheter, which can be set in place by the physician, will enable the direct cooling of the cerebrospinal fluid (CSF), which will in turn, cool the surrounding tissue.Each year 50,000 deaths, 235,000 hospital admissions and 1.1 million emergency room consults occur as a result of TBI. Moreover, nearly 90,000 of TBI patients will have long term damage as a result of the injury. Whole body hyperthermia has been shown to reduce the severity of TBI if administered quickly. But this approach has several drawbacks, including damage to peripheral tissues and organs. Thus, if successful, the proposed technology could have a powerful beneficial effect on TBI patients and is likely to reduce the morbidity and mortality associated with TBI.

这个小企业技术转让（STTR）第一阶段研究项目旨在开发一种用于冷却创伤性脑损伤（TBI）患者脑组织的导管。 该导管可由医生放置到位，可直接冷却脑脊液（CSF），进而冷却周围组织。每年有50，000例死亡，235，000例住院和110万例急诊室咨询是由于TBI。 此外，近90，000名TBI患者将因损伤而造成长期损害。 全身热疗已被证明，如果管理迅速，减少创伤性脑损伤的严重程度。 但这种方法有几个缺点，包括对周围组织和器官的损伤。 因此，如果成功，所提出的技术可能对TBI患者产生强大的有益影响，并可能降低与TBI相关的发病率和死亡率。