SBIR Phase I: Multi-Thickness Mode Harmonic Array

SBIR 第一阶段：多厚度模式谐波阵列

• 批准号: 0740464
• 负责人: Bahram Jadidian
• 金额: --
• 依托单位: J&W Medical LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0740464&HistoricalAwards=false
• 关键词: SBIR; Phase; Multi; Thickness; Mode

This Small Business Innovation Research (SBIR) Phase I project will design and develop a very broadband and high sensitivity probe via the use of multi-thickness mode single crystal ferroelectrics; having superior electromechanical coupling coefficient. The unique design of the proposed array probe will produce the required two-octave bandwidth for operating at the subharmonic, first harmonic and second harmonic frequencies. In this project, the first harmonic transmit/receive frequency will be 4.0 MHz with corresponding subharmonic and second harmonic echoes at 2.0 MHz and 8.0 MHz, respectively. This project will develop a single crystal linear array with multi-resonance frequencies. A 16-element array will be fabricated, utilizing the "dice and fill" method that is ideally suited for the frequency regime common to medical imaging (1-10 MHz). Feasibility will be demonstrated with measurement of the temporal and spectral scattered echo returns from a fluid with microbubble-based ultrasound contrast agent.The broader impact/commercial potential if successful, will be a significant advancement of numerous clinical applications, such as the enhanced detection of myocardial perfusion, perfusion abnormalities of kidney parenchyma, and liver tumors. The long-term goal is to develop a single probe amenable for several diagnostic studies: adult and pediatric abdominal, breast, peripheral vascular, small parts, musculoskeletal, and cardiac (sub-sternum).

该小型企业创新研究（SBIR）第一阶段项目将通过使用多厚度模式单晶铁电体来设计和开发一种非常宽带和高灵敏度的探针；具有优越的机电耦合系数。所提出的阵列探头的独特设计将产生在分谐波、一次谐波和二次谐波频率下工作所需的双倍频程带宽。在该项目中，一次谐波发射/接收频率将为 4.0 MHz，相应的次谐波和二次谐波回波频率分别为 2.0 MHz 和 8.0 MHz。该项目将开发具有多谐振频率的单晶线性阵列。将利用“切块和填充”方法制造 16 元件阵列，该方法非常适合医学成像常见的频率范围（1-10 MHz）。通过使用基于微泡的超声造影剂测量流体的时间和光谱散射回波返回来证明可行性。如果成功，更广泛的影响/商业潜力将是众多临床应用的重大进步，例如增强心肌灌注、肾实质灌注异常和肝脏肿瘤的检测。长期目标是开发适用于多种诊断研究的单一探头：成人和儿童腹部、乳房、周围血管、小部件、肌肉骨骼和心脏（胸骨下）。