The Adaptive Evolution Database: A Database of Phylogenetically-Indexed Gene Families

适应性进化数据库：系统发育索引基因家族数据库

• 批准号: 0743374
• 负责人: David Liberles
• 金额: $ 78.69万
• 依托单位: University of Wyoming
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0743374&HistoricalAwards=false
• 关键词: Adaptive; Evolution; Database; Phylogenetically; Indexed

The University of Wyoming has been awarded a grant to develop a database characterizing the evolution of Chordate gene families. To establish the database, several new computational approaches will be developed. These approaches include model-based methods for tracing the history of duplication and loss events in gene families through the evolution of species as well as methods describing the evolution of protein sequences given the thermodynamic constraints of protein structures. The new approaches coupled to the database as a resource for the biological community promise to offer new insights into Chordate evolution. The broader impacts include training in bioinformatics for researchers, Ph.D. students, and undergraduate students at the interface of molecular biology and mathematics. The database itself will be used as a teaching tool for bioinformatics instruction.

怀俄明州大学获得了一笔赠款，用于开发一个描述脊索动物基因家族进化特征的数据库。为了建立数据库，将开发几种新的计算方法。这些方法包括基于模型的方法，通过物种的进化来追踪基因家族中重复和丢失事件的历史，以及描述蛋白质序列进化的方法，给出了蛋白质结构的热力学约束。新的方法结合数据库作为生物界的资源，有望为脊索动物进化提供新的见解。更广泛的影响包括对研究人员进行生物信息学培训，学生和本科生在分子生物学和数学的接口。数据库本身将被用作生物信息学教学的教学工具。