Neurobiology of the Naked Mole-Rat
裸鼹鼠的神经生物学
基本信息
- 批准号:0744979
- 负责人:
- 金额:$ 70万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-01 至 2015-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objective of this project is to investigate adaptations in the peripheral and central nervous systems of the naked mole-rat. Naked mole-rats have an unusual lifestyle in that they combine a fully subterranean existence with extreme sociality, and a proclivity for living in large numbers. Thus, in their crowded burrows where many animals share a limited air supply, these animals are exposed to the challenges of breathing exceptionally high levels of carbon dioxide and exceptionally low levels of oxygen. Initial studies have revealed that, behaviorally, naked mole-rats are extremely resistant to high carbon dioxide and low oxygen. The goals of the project now are to better understand the underlying mechanisms that make this resistance possible. The project uses a variety of methods including behavioral, electrophysiological, anatomical, and molecular techniques with an emphasis on moving freely between experiments that focus on neural mechanisms and those that focus on natural behaviors. The project also relies heavily on comparative data from closely and distantly related species that have evolved under different carbon dioxide and oxygen conditions. The expected impacts of this project include contributing to the understanding of the nervous system in general, and to adaptations to environmental challenges in particular. Also, the project will develop a new model system for studying the evolution of the nervous system and behavior. The project will provide training opportunities in systems neuroscience for both graduate and undergraduate students. The project will also enhance laboratory courses in that several laboratory exercises have been developed with these animals.
本项目的目的是研究裸鼹鼠的外周和中枢神经系统的适应性。裸鼹鼠有一种不同寻常的生活方式,它们联合收割机结合了完全的地下生活和极端的社会性,以及大量生活的倾向。 因此,在拥挤的洞穴中,许多动物共享有限的空气供应,这些动物面临着呼吸异常高水平的二氧化碳和异常低水平的氧气的挑战。初步研究表明,裸鼹鼠的行为对高二氧化碳和低氧具有极强的抵抗力。该项目现在的目标是更好地了解使这种耐药性成为可能的潜在机制。该项目使用了多种方法,包括行为,电生理,解剖和分子技术,重点是在专注于神经机制的实验和专注于自然行为的实验之间自由移动。 该项目还在很大程度上依赖于在不同二氧化碳和氧气条件下进化的近亲和远亲物种的比较数据。 该项目的预期影响包括促进对神经系统的理解,特别是适应环境挑战。 此外,该项目将开发一个新的模型系统,用于研究神经系统和行为的进化。该项目将为研究生和本科生提供系统神经科学的培训机会。 该项目还将加强实验室课程,因为已经用这些动物开发了一些实验室练习。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas Park其他文献
Urban Health Project: A Sustainable and Successful Community Internship Program for Medical Students
城市健康项目:针对医学生的可持续且成功的社区实习计划
- DOI:
10.1353/hpu.2015.0117 - 发表时间:
2015 - 期刊:
- 影响因子:1.4
- 作者:
Kasey Roberts;Thomas Park;N. Elder;Saundra L. Regan;S. Theodore;M. Mitchell;Yolanda N. Johnson - 通讯作者:
Yolanda N. Johnson
Late outcome following central nervous system injury in child abuse
虐待儿童中枢神经系统损伤后的后期结果
- DOI:
10.1007/s00381-002-0686-9 - 发表时间:
2003 - 期刊:
- 影响因子:0
- 作者:
E. Perez;M. Dujovny;Z. Delproposto;F. Vinas;Hun K. Park;Sandra Lizarraga;Thomas Park;F. Diaz - 通讯作者:
F. Diaz
CNS child abuse: Epidemiology and prevention
中枢神经系统虐待儿童:流行病学和预防
- DOI:
- 发表时间:
2002 - 期刊:
- 影响因子:1.9
- 作者:
E. Perez;M. Dujovny;F. Vinas;Hun K Park;Sandra Lizarraga;Thomas Park;F. Diaz - 通讯作者:
F. Diaz
Application of finite element analysis in neurosurgery
有限元分析在神经外科中的应用
- DOI:
- 发表时间:
2001 - 期刊:
- 影响因子:0
- 作者:
Hun K. Park;M. Dujovny;Thomas Park;F. Diaz - 通讯作者:
F. Diaz
In vitro models of microglia: a comparative study
- DOI:
10.1038/s41598-025-99867-z - 发表时间:
2025-05-05 - 期刊:
- 影响因子:3.900
- 作者:
Zoe Woolf;Taylor J. Stevenson;Kevin Lee;Blake Highet;Jena Macapagal Foliaki;Ramona Ratiu;Justin Rustenhoven;Jason Correia;Patrick Schweder;Peter Heppner;Maria Weinert;Natacha Coppieters;Thomas Park;Johanna Montgomery;Amy M. Smith;Michael Dragunow - 通讯作者:
Michael Dragunow
Thomas Park的其他文献
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{{ truncateString('Thomas Park', 18)}}的其他基金
The Neurobiology of Hypoxia Tolerance in the Naked Mole-Rat
裸鼹鼠耐缺氧的神经生物学
- 批准号:
2201647 - 财政年份:2022
- 资助金额:
$ 70万 - 项目类别:
Continuing Grant
Creation of a GIS for Six Cities in Arid Environments : In Morocco, Senegal, Mali, Niger, Tanzania, and Botswana
为干旱环境中的六个城市创建 GIS:摩洛哥、塞内加尔、马里、尼日尔、坦桑尼亚和博茨瓦纳
- 批准号:
9817743 - 财政年份:1999
- 资助金额:
$ 70万 - 项目类别:
Standard Grant
Dissertation Research: Ethnicity, State Intervention and Agricultural Intensification in the Ziz Valley, Morocco
论文研究:摩洛哥齐兹山谷的种族、国家干预和农业集约化
- 批准号:
9321194 - 财政年份:1994
- 资助金额:
$ 70万 - 项目类别:
Standard Grant
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Naked1通过调控P53抑制肝癌细胞增殖的机制研究
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- 批准年份:2014
- 资助金额:23.0 万元
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- 批准号:30971524
- 批准年份:2009
- 资助金额:31.0 万元
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The Neurobiology of Hypoxia Tolerance in the Naked Mole-Rat
裸鼹鼠耐缺氧的神经生物学
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2201647 - 财政年份:2022
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$ 70万 - 项目类别:
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Comparative genomic, epigenomic, and transcriptomic interrogation of pubertal onset in the naked mole-rat hypothalamus.
裸鼹鼠下丘脑青春期起始的比较基因组、表观基因组和转录组学研究。
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