Exploring Genomic Targets of Selection during Parallel Niche Expansions

探索平行生态位扩展期间选择的基因组目标

• 批准号: 0745828
• 负责人: Carol Lee
• 金额: --
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2011-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0745828&HistoricalAwards=false
• 关键词: Exploring; Genomic; Targets; Selection; during

Many species are introduced into new habitats, but only a small percentage survive and become harmful. This project will explore the genes that undergo natural selection after a species invades freshwater lakes and reservoirs from saline habitats asking: Are the same genes involved during repeated and independent invasions? The study uses as a model a small crustacean, the copepod Eurytemora affinis, that was introduced to freshwater systems in North America through ship traffic. The project (1) will identify genomic regions that are directly linked to freshwater adaptation and (2) analyze whether shared genetic mechanisms might be involved across independent invasions. The genes, or locations in the genome will be identified through quantitative trait loci (QTL)-mapping, using both standard and high-resolution approaches. These analyses will be performed for multiple independent invasions to determine whether the same genomic regions are involved.Biological invasions have enormous impacts on ecosystem integrity, commerce, and public health, with economic costs of approximately $150 billion per year in the US alone. The Great Lakes are heavily affected, and serve as a major corridor for inland invasions. Knowing the genes and traits that undergo selection during invasions would provide insights into why only certain species invade, potentially providing the means to stop them. The project will also help train undergraduate and graduate students.

许多物种被引入新的栖息地，但只有一小部分存活下来并变得有害。该项目将探索一个物种从盐水栖息地入侵淡水湖泊和水库后经历自然选择的基因，并询问：在重复和独立的入侵过程中是否涉及相同的基因？这项研究使用一种小型甲壳类动物，桡足类Eurytemora affinis作为模型，它是通过船舶交通引入北美淡水系统的。该项目（1）将确定与淡水适应直接相关的基因组区域，（2）分析是否可能涉及独立入侵的共享遗传机制。基因或基因组中的位置将通过数量性状基因座（QTL）定位，使用标准和高分辨率的方法来确定。这些分析将对多个独立的入侵进行，以确定是否涉及相同的基因组区域。生物入侵对生态系统的完整性，商业和公共卫生产生巨大影响，仅在美国每年的经济成本就约为1500亿美元。五大湖受到严重影响，成为入侵内陆的主要通道。了解在入侵过程中经历选择的基因和特征将有助于了解为什么只有某些物种入侵，并可能提供阻止它们的方法。该项目还将帮助培训本科生和研究生。

项目成果

Zebra mussels anchor byssal threads faster and tighter than quagga mussels in flow

斑马贻贝在流动中比斑驴贻贝锚定足丝更快更紧

• DOI: 10.1242/jeb.028688
• 发表时间: 2009
• 期刊: Journal of Experimental Biology
• 影响因子: 2.8
• 作者: Peyer, Suzanne M.;McCarthy, Alice J.;Lee, Carol Eunmi
• 通讯作者: Lee, Carol Eunmi

Without Gills: Localization of Osmoregulatory Function in the Copepod Eurytemora affinis

• DOI: 10.1086/674319
• 发表时间: 2014-03-01
• 期刊: PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
• 影响因子: 1.6
• 作者: Johnson, Kelsey Elizabeth;Perreau, Lucile;Lee, Carol Eunmi
• 通讯作者: Lee, Carol Eunmi