CAREER: Heterogeneous Cell Carriers to Promote Gradiated Tissue Formation Under Mechanical Loading - An Integrated Education and Research Study

职业：异质细胞载体促进机械负载下梯度组织的形成 - 一项综合教育和研究

• 批准号: 0746209
• 负责人: Johnna Temenoff
• 金额: $ 40万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0746209&HistoricalAwards=false
• 关键词: CAREER; Heterogeneous; Cell; Carriers; Promote

0746209TemenoffAbstractInterfaces between different tissue types are found throughout the body and are crucial to the proper functions of all major organ systems. However, in many cases, it remains unclear how these interfaces form, making it extremely difficult to recreate appropriate interactions between disparate tissues after injury. An anticipated outcome of this project is that a controlled, three-dimensional coculture system as a model for interface development in orthopaedic tissues will be developed. This project is significant because the model system will provide key information about the role of cell-matrix interactions in promoting a gradient of phenotypic expression by mesenchymel stem cells (MSCs) under tensile loading, such as that experienced at the bone-ligament interface in vivo. The education project includes the creation of new and innovative teaching materials at the high school, college, and graduate levels that will advance understanding and appreciation of the complex processes required to assure safety of modern biomaterials, and highlight limitations of current biomaterials.

不同组织类型之间的接口存在于全身各处，对所有主要器官系统的正常功能至关重要。然而，在许多情况下，这些界面是如何形成的尚不清楚，这使得在损伤后重建不同组织之间的适当相互作用变得极其困难。该项目的一个预期结果是，将开发一种受控的三维共培养系统，作为骨科组织界面开发的模型。这个项目意义重大，因为该模型系统将提供有关细胞-基质相互作用在促进间充质干细胞(MSCs)在拉伸载荷下的表型表达梯度中的作用的关键信息，例如在体内经历的骨-韧带界面的表达。该教育项目包括在高中、大学和研究生层面创建新的创新教材，以促进对确保现代生物材料安全所需的复杂过程的理解和欣赏，并突出当前生物材料的局限性。