Exploring the Heterogeneous Biogenesis Pathways of the Bacterial Cell Envelope.

在细菌中，细胞包膜是防御和致病性的前线。关键的蛋白质组装需要在细胞周围成熟、定位和组装蛋白质、糖和脂质，以保护细胞免受抗生素、噬菌体和毒素的侵害，并调节细胞结构和形状。其中一个主要组成部分是基本的细胞外细胞壁，它在细胞周围形成网状的外壳。它的组装是许多抗生素的目标。在这里，我们将使用分子模拟来研究负责细胞壁形成的蛋白质机制和细胞包膜内的其他生物发生途径。

The cell envelope serves as the front-line to both defence and pathogenicity in bacteria. Critical protein assemblies are required to mature, localise and assemble proteins, sugars and lipids around the cell to enable protection against antibiotics, phages and toxins, and to modulate cell structure and shape. A major component of this is the essential extracellular cell wall, which forms a mesh-like coat around the cell. Its assembly is the target for many antibiotics. Here we will use molecular simulation to study the protein machinery responsible for the formation of the cell wall and other biogenesis pathways within the cell envelope.