CAREER: Macromolecular Materials Based on the Diverse Chemistry of Arylboronic Acids and Arylboroxines

有了这个职业奖，有机和高分子化学计划正在支持圣地亚哥大学的Peter Iovine教授的研究。 Iovine教授将应用芳基硼酸和芳基硼氧烷的不同化学来合成新材料。 首先，我们将发展一种操作简单的合成方法，以合理地控制芳基环硼氧烷化合物的取代模式。 第二，小分子芳基环硼氧烷化学将被应用于含三脚架芳基环硼氧烷核的刘易斯酸性树枝状大分子的合成。 树枝状聚合物是由各个粘性末端树枝状分子的脱水缩合形成的，这些树枝状分子在其焦点处具有单个芳基硼酸官能团。 研究了刘易斯碱性客体分子与活性核的可逆结合以及这些客体分子在树枝状聚合物中的迁移。 在最终的目标中，硼酸尖端的树枝状分子将被用作大分子试剂，对可再生材料进行化学修饰。Iovine教授还将启动两个教育项目，将研究和教学结合起来。 第一个项目涉及一个针对当地两所学校的外联方案，这两所学校主要为代表性不足的群体服务。 在与当地教育工作者建立工作关系后，Iovine教授将为本科理科专业设计和教授一门课程，探索与科学推广相关的社会影响和最佳实践。 第二个教育计划将教师或工业合作伙伴的研究注入到上层部门的讲座/实验室课程中。 一个学期的三分之一将致力于从部门教师或当地行业合作伙伴培养的开放式研究项目。

With this CAREER Award, the Organic and Macromolecular Chemistry program is supporting the research of Professor Peter Iovine of the University of San Diego. Professor Iovine will apply the diverse chemistry of arylboronic acids and arylboroxines to the synthesis of new materials. First, an operationally simple synthetic methodology will be developed to rationally control the substitution pattern in arylboroxine compounds. Second, small molecule arylboroxine chemistry will be applied to the synthesis of Lewis acidic dendrimers containing tripodal arylboroxine cores. The dendrimers are formed by the dehydration condensation of individual sticky-ended dendrons, which have at their focal point, a single arylboronic acid functional group. The reversible binding of Lewis basic guest molecules to the reactive core as well as the migration of these guests in and out of the dendrimer will be studied. In the final objective, boronic acid-tipped dendrons will be used as macromolecular reagents to chemically modify renewable materials.Professor Iovine will also initiate two educational projects that interweave research and teaching. The first project involves an outreach program targeting two local schools that serve predominantly underrepresented groups. After establishing working relationships with the local educators, Professor Iovine will design and teach a course to undergraduate science majors exploring the societal implications and best practices associated with scientific outreach. The second educational initiative infuses faculty or industrial partner research into upper-division lecture/laboratory courses. One third of a semester will be devoted to open-ended research projects that are cultivated from Departmental faculty or local industry partners.