CAREER: Investigations of Zirconium-Catalyzed Phosphorus-Element Bond-Forming Reactions

职业：锆催化磷元素成键反应的研究

• 批准号: 0747612
• 负责人: Rory Waterman
• 金额: $ 62.3万
• 依托单位: University of Vermont & State Agricultural College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0747612&HistoricalAwards=false
• 关键词: CAREER; Investigations; Zirconium; Catalyzed; Phosphorus

This award by the Inorganic, Bioinorganic, and Organometallic Chemistry Program and the Experimental Program to Stimulate Competitive Research (EPSCoR) to Professor Rory Waterman of the University of Vermont and State Agricultural College addresses catalytic methodologies used to form bonds between phosphorus and other main-group elements. The research has particular relevance due to the importance of phosphorus-containing molecules in biology, fine chemicals (including chiral phosphine ligands), polymers, and materials science. Specifically, the research will investigate zirconium-mediated reactions that catalytically activate phosphorus-hydrogen bonds to form new molecules in useful and selective ways. Catalytic reactions that build phosphorus-element bonds are quite rare yet, but with a greater understanding of the fundamental processes that govern these bonds, new catalysis reactions are envisioned which will improve selectivity and afford novel products. Through a Project SEED program established by the PI at the University of Vermont, economically disadvantaged and underrepresented minority high school students will be encouraged to participate in summer research alongside University of Vermont graduate and undergraduate students. The PI will also develop a new general chemistry course directed at educating undergraduates in civic science literacy with the goal of reducing the difference in understanding practical science between science and non-science majors.

这一奖项由无机化学、生物无机化学和有机金属化学计划以及刺激竞争研究的实验计划(EPSCoR)颁发给佛蒙特州大学和州立农业学院的罗里·沃特曼教授，该奖项旨在介绍用于在磷和其他主族元素之间形成键的催化方法。由于含磷分子在生物学、精细化学品(包括手性膦配体)、聚合物和材料科学中的重要性，这项研究具有特别的相关性。具体地说，这项研究将研究以有用和选择性的方式催化激活磷-氢键以形成新分子的锆介导反应。建立磷元素键的催化反应还很少见，但随着对支配这些键的基本过程的更多了解，新的催化反应将被设想，这将提高选择性并提供新的产品。通过由佛蒙特大学PI建立的SEED项目，将鼓励经济困难和代表不足的少数族裔高中生与佛蒙特州大学的研究生和本科生一起参加暑期研究。该协会还将开发一门新的普通化学课程，旨在教育本科生公民科学素养，目的是缩小理科和非理科专业学生对实用科学的理解差异。