PFI-TT: Expanding the Market Share of Domestically Produced Primary Phosphines

PFI-TT：扩大国产原生膦市场份额

• 批准号: 2329625
• 负责人: Rory Waterman
• 金额: $ 54.54万
• 依托单位: University of Vermont & State Agricultural College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2329625&HistoricalAwards=false
• 关键词: PFI; TT; Expanding; Market; Share

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project is the support for the economic development resulting from a diversified chemical feedstock. Primary phosphines, organophosphorus compounds containing a single organic substituent, are important chemical precursors. Their use can benefit agriculture, biomedicine, materials science, and consumer goods by supporting efficient preparation of a wide range of known, useful products that benefit society as well as to help develop new products. Current technology that produces primary phosphines is highly wasteful and hazardous. This project’s technology provides these products with increased safety and reduced waste, which can expand domestic chemical production. This project leverages catalysis and supports further growth of this environmentally friendly, multi-billion-dollar industry. The project team has a strong record of involving individuals from marginalized identities in science to expand the future STEM workforce. Such efforts will continue to serve national and state workforce development goals. Additionally, part of this project will aid in the long-term development of entrepreneurship education to yield regional students who will be better prepared for technology transfer and conversion of science to market-ready products in the future. The proposed project seeks to transition an NSF-funded discovery to a viable marketplace technology. To meet this goal, Lewis acid catalysis will be used to prepare primary phosphines. Lewis acid catalysis has become a topic of tremendous interest including recognition by the 2022 Nobel Prize in Chemistry. Application of these cutting-edge discoveries will address the key challenge in primary phosphine synthesis, which is to move away from hazardous metal-based reducing agents. Goals of the project include expansion of the primary phosphines that can be prepared by this method, exploration of alternative catalysts including solid state catalysts, and preparations for growth to pilot scale production. The applied research plan directly addresses the more practical utilization of Lewis acid catalysis in the preparation of value-added products. The project aims to support new technology and new products in the marketplace. In meeting these goals, opportunities for Lewis acid catalysis in the preparation of commodity chemicals will be expanded through a greater understanding of their reactivity, especially at scale. The ability to utilize alternative Lewis acids would also be realized through this project, and additional aspects of phosphorus chemistry will be understood.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这一创新-技术转化伙伴关系（PFI-TT）项目更广泛的影响/商业潜力是支持多样化化学原料带来的经济发展。伯膦是一种含有单一有机取代基的有机磷化合物，是重要的化学前体。它们的使用可以使农业、生物医学、材料科学和消费品受益，支持有效制备各种有益于社会的已知有用产品，并有助于开发新产品。目前生产初级膦的技术是高度浪费和危险的。该项目的技术为这些产品提供了更高的安全性和更少的浪费，这可以扩大国内化学品生产。该项目利用催化作用，并支持这一环境友好型数十亿美元产业的进一步发展。该项目团队在让科学界边缘化身份的个人参与进来以扩大未来STEM劳动力方面有着良好的记录。这些努力将继续服务于国家和州的劳动力发展目标。此外，该项目的一部分将有助于创业教育的长期发展，以培养区域学生，他们将为未来的技术转让和科学转化为市场产品做好更好的准备。拟议的项目旨在将NSF资助的发现转变为可行的市场技术。为了实现这一目标，将使用刘易斯酸催化来制备伯膦。刘易斯酸催化已经成为一个非常有趣的话题，包括2022年诺贝尔化学奖的认可。这些前沿发现的应用将解决初级膦合成中的关键挑战，即摆脱危险的金属基还原剂。该项目的目标包括扩大可以通过这种方法制备的初级膦，探索包括固态催化剂在内的替代催化剂，以及为扩大到中试规模生产做准备。应用研究计划直接解决了刘易斯酸催化在制备增值产品中的更实际的利用。该项目旨在支持市场上的新技术和新产品。在实现这些目标的过程中，将通过更好地了解刘易斯酸的反应性，特别是在规模上，来扩大其在商品化学品制备中的催化机会。利用替代刘易斯酸的能力也将通过这个项目实现，磷化学的其他方面将得到理解。这个奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。