PFI-TT: Expanding the Market Share of Domestically Produced Primary Phosphines

这个创新伙伴关系-技术转化（PFI-TT）项目的更广泛的影响/商业潜力是对多样化化学原料带来的经济发展的支持。伯膦是一种含有单一有机取代基的有机磷化合物，是重要的化学前体。它们的使用可以使农业、生物医学、材料科学和消费品受益，因为它支持有效地制备一系列已知的、有用的产品，这些产品有益于社会，并有助于开发新产品。目前生产初级膦的技术是非常浪费和危险的。该项目的技术提高了这些产品的安全性，减少了废物，可以扩大国内化学品的生产。该项目利用催化技术，支持这一环境友好、价值数十亿美元的产业的进一步发展。该项目团队在让来自边缘身份的个人参与科学以扩大未来STEM劳动力方面有着良好的记录。这些努力将继续为国家和州的劳动力发展目标服务。此外，该项目的一部分将有助于企业精神教育的长期发展，以培养区域学生，使他们为将来的技术转让和将科学转化为市场产品做好更充分的准备。拟议的项目旨在将nsf资助的发现转化为可行的市场技术。为了实现这一目标，路易斯酸催化将用于制备伯膦。路易斯酸催化已成为备受关注的话题，并获得了2022年诺贝尔化学奖的认可。这些前沿发现的应用将解决初级膦合成的关键挑战，即远离危险的金属基还原剂。该项目的目标包括扩大该方法可制备的初级膦，探索包括固态催化剂在内的替代催化剂，并为中试规模生产做准备。应用研究计划直接解决了Lewis酸催化在制备高附加值产品中的更实际应用。该项目旨在支持市场上的新技术和新产品。为了实现这些目标，将通过对Lewis酸催化的反应性，特别是在规模上的反应性有更深入的了解，扩大其在制备商品化学品方面的机会。利用替代路易斯酸的能力也将通过该项目实现，并将了解磷化学的其他方面。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project is the support for the economic development resulting from a diversified chemical feedstock. Primary phosphines, organophosphorus compounds containing a single organic substituent, are important chemical precursors. Their use can benefit agriculture, biomedicine, materials science, and consumer goods by supporting efficient preparation of a wide range of known, useful products that benefit society as well as to help develop new products. Current technology that produces primary phosphines is highly wasteful and hazardous. This project’s technology provides these products with increased safety and reduced waste, which can expand domestic chemical production. This project leverages catalysis and supports further growth of this environmentally friendly, multi-billion-dollar industry. The project team has a strong record of involving individuals from marginalized identities in science to expand the future STEM workforce. Such efforts will continue to serve national and state workforce development goals. Additionally, part of this project will aid in the long-term development of entrepreneurship education to yield regional students who will be better prepared for technology transfer and conversion of science to market-ready products in the future. The proposed project seeks to transition an NSF-funded discovery to a viable marketplace technology. To meet this goal, Lewis acid catalysis will be used to prepare primary phosphines. Lewis acid catalysis has become a topic of tremendous interest including recognition by the 2022 Nobel Prize in Chemistry. Application of these cutting-edge discoveries will address the key challenge in primary phosphine synthesis, which is to move away from hazardous metal-based reducing agents. Goals of the project include expansion of the primary phosphines that can be prepared by this method, exploration of alternative catalysts including solid state catalysts, and preparations for growth to pilot scale production. The applied research plan directly addresses the more practical utilization of Lewis acid catalysis in the preparation of value-added products. The project aims to support new technology and new products in the marketplace. In meeting these goals, opportunities for Lewis acid catalysis in the preparation of commodity chemicals will be expanded through a greater understanding of their reactivity, especially at scale. The ability to utilize alternative Lewis acids would also be realized through this project, and additional aspects of phosphorus chemistry will be understood.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.