CAREER: Design of Colorimetric and Chiroptical Sensors for Illegal Substances
职业:非法物质比色和手性光学传感器的设计
基本信息
- 批准号:0747949
- 负责人:
- 金额:$ 52.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-02-01 至 2014-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With the support of the Organic and Macromolecular Chemistry Program at the National Science Foundation, Professor Andrea Holmes of Doane College in Crete, Nebraska will develop new macromolecular color sensors for the detection of abused narcotics. Professor Holmes, a post-doctoral research associate, and an undergraduate research team will work primarily toward the design of sensors for chiral drugs such as cocaine and methamphetamine by 1) developing molecular color sensors from aptamers (oligonucleotide-based binders) that change color in the presence of small quantities of drugs, 2) testing the utilization of circular dichroism (CD) spectroscopy as a technique for discriminating between the enantiomers of chiral drugs that are often abused, and 3) developing a solid matrix that allows the new chemical sensors to be attached to a solid support for actual use outside the laboratory in a field test product. The organic synthetic and analytical techniques used include solid-phase synthesis, the determination of binding constants by UV/Vis and fluorescence spectroscopy, combinatorial 96-well plate methods, circular dichroism spectroscopy, and MALDI-TOF or Electrospray Ionization mass spectrometry. The exploration of incorporating aptamer sensors into sol-gels reflects the creative symbiosis of solution phase and solid phase chemistry.Results from this CAREER award will provide an improved understanding of achiral host and chiral drug interactions and the development of a library of aptamer-dye structures that are sensitive and specific to abused narcotics. The work may eventually lead to new drug-detection tools for forensic scientists and others. The PI will integrate the research into undergraduate courses in organic chemistry in classes enrolling predominantly rural students, many of whom intend to become science teachers. Students participating on the research team will provide classroom activities for local middle school students and return to their own high schools as science mentors.
在美国国家科学基金会有机和大分子化学项目的支持下,内布拉斯加州克里特岛多恩学院的安德里亚·霍姆斯教授将开发新型大分子颜色传感器来检测滥用毒品。霍姆斯教授,一个博士后研究助理,和一个本科生研究小组将主要致力于设计手性药物,如可卡因和甲基苯丙胺的传感器,通过1)从适体开发分子颜色传感器(基于阿糖胞苷的粘合剂),在少量药物存在下会改变颜色,2)测试圆二色性(CD)光谱作为区分经常被滥用的手性药物的对映体的技术的利用,以及3)开发固体基质,其允许新的化学传感器附着到固体支持物上,用于在实验室外的现场测试产品中的实际使用。所用的有机合成和分析技术包括固相合成、通过UV/维斯和荧光光谱法测定结合常数、组合96孔板方法、圆二色谱法和MALDI-TOF或电喷雾电离质谱法。将适体传感器结合到溶胶-凝胶中的探索反映了溶液相和固相化学的创造性共生。这项CAREER奖的结果将提供对非手性宿主和手性药物相互作用的更好理解,以及开发对滥用麻醉品敏感和特异的适体染料结构库。这项工作最终可能会为法医科学家和其他人带来新的毒品检测工具。PI将把这项研究纳入有机化学本科课程,主要招收农村学生,其中许多人打算成为科学教师。参加研究小组的学生将为当地中学生提供课堂活动,并返回自己的高中担任科学导师。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Andrea Holmes其他文献
Prospective Single-Arm Feasibility of Supervised Virtual Exercise in Women Living with Ovarian Cancer: The BE-BALANCED Study
卵巢癌女性监督虚拟锻炼的前瞻性单臂可行性:BE-BALANCED 研究
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0.9
- 作者:
Rafael A. Fujita;Anna Tinker;Natalie Fujisawa;Andrea Holmes;Gillian E. Hanley;Dawn C. Mackey;Linda Trinh;Iris Lesser;Kelly A. Mackenzie;Ashley Larnder;Rachel A. Murphy;Gillian V. H. Smith;Jee A. Lam;Kristin L. Campbell - 通讯作者:
Kristin L. Campbell
Genome science: a video tour of the Washington University Genome Sequencing Center for high school and undergraduate students.
基因组科学:面向高中生和本科生的华盛顿大学基因组测序中心视频之旅。
- DOI:
10.1187/cbe.05-07-0088 - 发表时间:
2005 - 期刊:
- 影响因子:0
- 作者:
Susan K. Flowers;C. Easter;Andrea Holmes;Brian Cohen;April E. Bednarski;E. Mardis;R. Wilson;S. Elgin - 通讯作者:
S. Elgin
Hemp on the horizon: Understanding the influences on industrial hemp purchases
大麻即将到来:了解对工业大麻采购的影响
- DOI:
10.37433/aad.v3i3.189 - 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Taylor K. Ruth;Blake C. Colclasure;N. Conner;Andrea Holmes;Tessa Durham Brooks - 通讯作者:
Tessa Durham Brooks
Will flight-shaming influence the future of air travel?
飞行羞辱会影响航空旅行的未来吗?
- DOI:
10.1093/jtm/taz088 - 发表时间:
2019 - 期刊:
- 影响因子:25.7
- 作者:
G. Flaherty;Andrea Holmes - 通讯作者:
Andrea Holmes
Post-exposure prophylaxis, STI testing and factors associated with follow-up attendance: a review of 4159 cases of acute post-sexual assault medical care
暴露后预防、性传播感染检测和随访相关因素:对 4159 例急性性侵犯后医疗护理案例的回顾
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:3.6
- 作者:
D. Kane;Andrea Holmes;M. Eogan - 通讯作者:
M. Eogan
Andrea Holmes的其他文献
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{{ truncateString('Andrea Holmes', 18)}}的其他基金
International Undergraduate Research Experience: The Development and Application of Novel Micro- and Nano-Sized Sensing Arrays Capable of Detecting Small Molecules
国际本科生研究经验:可检测小分子的新型微纳尺寸传感阵列的开发与应用
- 批准号:
1459838 - 财政年份:2015
- 资助金额:
$ 52.5万 - 项目类别:
Standard Grant
Incorporating Circular Dichroism in the Undergraduate Chemistry Curriculum
将圆二色性纳入本科化学课程
- 批准号:
0633462 - 财政年份:2007
- 资助金额:
$ 52.5万 - 项目类别:
Standard Grant
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