CAREER: Synthetic methodology for the preparation of polycyclic nitrogen or oxygen containing heterocycles

职业：制备多环氮或氧杂环的合成方法

• 批准号: 0748058
• 负责人: Matthias Brewer
• 金额: $ 50万
• 依托单位: University of Vermont & State Agricultural College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0748058&HistoricalAwards=false
• 关键词: CAREER; Synthetic; methodology; preparation; polycyclic

With this CAREER Award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Matthias Brewer of the Chemistry Department at the University of Vermont. This project will develop new methods for the synthesis of nitrogen or oxygen containing organic compounds from simple starting materials. These methods, based on the reaction of hydrazones with sulfonium ions, will provide new ways to access reactive intermediates under mild and environmentally benign conditions. These reactive intermediates will be studied for their ability to participate in unprecedented sigmatropic rearrangements, electrophilic aromatic substitutions, and cycloadditions, and will also be evaluated for reactivity in a variety of synthetic transformations. This research will provide biomedical researchers with new tools to prepare biologically active compounds that are often difficult to synthesize by current methods.Professor Brewer will also initiate educational projects focused on the development of environmentally beneficial green chemical methods and their integration into the undergraduate curriculum. Green chemistry experiments will be developed in senior-level organic laboratories for use in the lower-level undergraduate laboratories. The PI will also oversee a partnership between undergraduate students and a local aquarium/science center to develop outreach educational materials designed to introduce a general audience to environmentally benign green chemistry.

有了这个职业奖，有机和高分子化学计划正在支持佛蒙特大学化学系教授马蒂亚斯布鲁尔的研究。 该项目将开发从简单起始原料合成含氮或含氧有机化合物的新方法。 这些方法，基于腙与锍离子的反应，将提供新的途径，在温和和环境友好的条件下获得活性中间体。这些反应性中间体将研究他们的能力，参与前所未有的sigmatropic重排，亲电芳族取代，和环加成，也将在各种合成转化的反应性进行评估。这项研究将为生物医学研究人员提供新的工具，以制备通常难以通过当前方法合成的生物活性化合物。Brewer教授还将发起教育项目，重点是开发对环境有益的绿色化学方法，并将其融入本科课程。 在高层次有机实验室开展绿色化学实验，供低层次本科生实验室使用。 PI还将监督本科生和当地水族馆/科学中心之间的合作伙伴关系，以开发旨在向普通观众介绍环境友好的绿色化学的宣传教育材料。