CAREER: Synthetic methodology for the preparation of polycyclic nitrogen or oxygen containing heterocycles

有了这个职业奖，有机和大分子化学项目支持佛蒙特大学化学系的Matthias Brewer教授的研究。该项目将开发从简单原料合成含氮或含氧有机化合物的新方法。这些基于腙与磺酸离子反应的方法将为在温和和环境友好的条件下获得活性中间体提供新的途径。这些反应性中间体将研究其参与前所未有的符号重排，亲电芳香取代和环加成的能力，并将评估其在各种合成转化中的反应性。这项研究将为生物医学研究人员提供新的工具来制备生物活性化合物，这些化合物通常很难用现有的方法合成。布鲁尔教授还将发起教育项目，重点发展对环境有益的绿色化学方法，并将其纳入本科课程。在高级有机实验室发展绿色化学实验，供低级本科实验室使用。PI还将监督本科生与当地水族馆/科学中心之间的伙伴关系，开发旨在向普通观众介绍无害环境的绿色化学的外展教育材料。

With this CAREER Award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Matthias Brewer of the Chemistry Department at the University of Vermont. This project will develop new methods for the synthesis of nitrogen or oxygen containing organic compounds from simple starting materials. These methods, based on the reaction of hydrazones with sulfonium ions, will provide new ways to access reactive intermediates under mild and environmentally benign conditions. These reactive intermediates will be studied for their ability to participate in unprecedented sigmatropic rearrangements, electrophilic aromatic substitutions, and cycloadditions, and will also be evaluated for reactivity in a variety of synthetic transformations. This research will provide biomedical researchers with new tools to prepare biologically active compounds that are often difficult to synthesize by current methods.Professor Brewer will also initiate educational projects focused on the development of environmentally beneficial green chemical methods and their integration into the undergraduate curriculum. Green chemistry experiments will be developed in senior-level organic laboratories for use in the lower-level undergraduate laboratories. The PI will also oversee a partnership between undergraduate students and a local aquarium/science center to develop outreach educational materials designed to introduce a general audience to environmentally benign green chemistry.