Signalling function and metabolism of extracellular nucleotides in plants

植物细胞外核苷酸的信号功能和代谢

• 批准号: 185591125
• 负责人: Dr. Iris Steinebrunner
• 金额: --
• 依托单位: Fachgebiet Pflanzenphysiologie
• 依托单位国家: 德国
• 项目类别: Scientific Networks
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/185591125?language=en
• 关键词: Signalling; function; metabolism; extracellular; nucleotides

ATP does not only drive energy-dependent reactions inside cells; but can also function outside the plasma membrane in the extracellular matrix as a signalling molecule. This external role of ATP is well established in animal cells, but not until recently it has become apparent that extracellular ATP (eATP) can also function as a signalling agent in plants. Besides elucidation of the signal transduction machinery it is of interest to investigate how eATP is degraded and salvaged. Two of the three partners will provide their expertise in plant eATP signalling and salvage. The third partner combines experience both from the animal and plant field and will contribute his biochemical expertise to understand the, regulation of eATP. Together, we aim to intensify scientific exchange and promote collaborations between partner laboratories.Young scientists will benefit from the opportunity for scientific feedback at yearly network meetings and for broadening their experimental skills by mutual research visits. This network (eight members in total with seven junior scientists at different levels and one full professor) will help to shed light on the role of eATP from different angles and will boost this growing field in plant science.

ATP 不仅驱动细胞内的能量依赖反应，而且还驱动细胞内的能量依赖性反应。但也可以在质膜外的细胞外基质中作为信号分子发挥作用。 ATP 的这种外部作用在动物细胞中已得到充分证实，但直到最近，细胞外 ATP (eATP) 也可以作为植物中的信号剂发挥作用才变得明显。除了阐明信号转导机制之外，研究 eATP 如何降解和回收也很有意义。三个合作伙伴中的两个将提供他们在植物 eATP 信号传导和挽救方面的专业知识。第三位合作伙伴结合了动植物领域的经验，并将贡献他的生化专业知识来了解 eATP 的调节。我们共同致力于加强科学交流并促进合作伙伴实验室之间的合作。年轻科学家将有机会在年度网络会议上获得科学反馈，并通过相互研究访问来拓宽他们的实验技能。该网络（共有八名成员，其中七名不同级别的初级科学家和一名正教授）将有助于从不同角度阐明 eATP 的作用，并将推动植物科学这一不断发展的领域。