Signalling function and metabolism of extracellular nucleotides in plants

ATP不仅驱动细胞内的能量依赖性反应，而且还可以在细胞外基质中的质膜外作为信号分子发挥作用。ATP的这种外部作用在动物细胞中得到了很好的证实，但直到最近才发现细胞外ATP（eATP）也可以作为植物中的信号传导剂。除了阐明的信号转导机制，它是感兴趣的研究如何eATP的降解和抢救。三个合作伙伴中的两个将提供其在电厂eATP信号和救助方面的专业知识。第三位合伙人结合了动物和植物领域的经验，并将贡献他的生化专业知识来了解eATP的调节。我们共同致力于加强科学交流，促进合作实验室之间的合作。青年科学家将受益于在年度网络会议上获得科学反馈的机会，并通过相互研究访问扩展他们的实验技能。这个网络（共有八名成员，七名不同级别的初级科学家和一名正教授）将有助于从不同角度阐明eATP的作用，并将推动植物科学中这一不断发展的领域。

ATP does not only drive energy-dependent reactions inside cells; but can also function outside the plasma membrane in the extracellular matrix as a signalling molecule. This external role of ATP is well established in animal cells, but not until recently it has become apparent that extracellular ATP (eATP) can also function as a signalling agent in plants. Besides elucidation of the signal transduction machinery it is of interest to investigate how eATP is degraded and salvaged. Two of the three partners will provide their expertise in plant eATP signalling and salvage. The third partner combines experience both from the animal and plant field and will contribute his biochemical expertise to understand the, regulation of eATP. Together, we aim to intensify scientific exchange and promote collaborations between partner laboratories.Young scientists will benefit from the opportunity for scientific feedback at yearly network meetings and for broadening their experimental skills by mutual research visits. This network (eight members in total with seven junior scientists at different levels and one full professor) will help to shed light on the role of eATP from different angles and will boost this growing field in plant science.