Superelectrophilic Considerations in Heterocyclic Chemistry

杂环化学中的超亲电考虑因素

• 批准号: 0749907
• 负责人: Douglas Klumpp
• 金额: $ 33万
• 依托单位: Northern Illinois University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0749907&HistoricalAwards=false
• 关键词: Superelectrophilic; Considerations; Heterocyclic; Chemistry

This project involves the development of new synthetic methods for the preparation of heterocyclic ring systems and their functionalized derivatives. The chemistry exploits the high reactivities of superelectrophilic species to accomplish the synthetic objectives. Other aspects of the project examine the critical structure-activity relationships of the superelectrophiles. These mechanistic studies (including theoretical calculations) will help to better understand the chemistry of the superelectrophiles. As a result of this project, the potential impact of superelectrophiles in biochemical transformations can also be established.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Douglas A. Klumpp of the Department of Chemistry and Biochemistry at Northern Illinois University. Professor Klumpp's research centers on the chemistry of highly reactive electrophiles. Electrophilic chemistry is of broad importance in biological processes, in the actions of medicines and drugs, and in facilitating the chemical conversions in the chemical industry. Successful completion of the proposed research will consequently have an impact in these areas of science, medicine, and industry.

该项目涉及开发制备杂环系统及其功能化衍生物的新合成方法。 该化学利用超亲电物质的高反应性来实现合成目标。 该项目的其他方面研究了超亲电体的关键结构-活性关系。 这些机理研究（包括理论计算）将有助于更好地理解超亲电体的化学性质。 由于这个项目，超亲电体在生物化学转化中的潜在影响也可以建立。有了这个奖项，有机和大分子化学计划是支持道格拉斯教授的研究。他是北方伊利诺斯大学化学和生物化学系的Klumpp博士。 Klumpp教授的研究中心是高反应性亲电试剂的化学。 亲电化学在生物过程、药物和药物的作用以及促进化学工业中的化学转化中具有广泛的重要性。 因此，成功完成拟议的研究将对科学，医学和工业等领域产生影响。