Superelectrophilic Considerations in Heterocyclic Chemistry

该项目涉及开发制备杂环体系及其官能化衍生物的新的合成方法。化学利用超亲电物种的高反应性来完成合成目标。该项目的其他方面研究了超亲电体的关键结构-活性关系。这些机理研究(包括理论计算)将有助于更好地理解超亲电分子的化学。这个项目的结果是，还可以确定超亲电体在生化转化中的潜在影响。有了这个奖项，有机和高分子化学计划正在支持北伊利诺伊大学化学和生物化学系的道格拉斯·A·克伦普教授的研究。克伦普教授的研究集中在高活性亲电体的化学上。亲电化学在生物过程、药物和药物的作用以及促进化学工业中的化学转化中具有广泛的重要性。因此，成功完成拟议的研究将对这些科学、医学和工业领域产生影响。

This project involves the development of new synthetic methods for the preparation of heterocyclic ring systems and their functionalized derivatives. The chemistry exploits the high reactivities of superelectrophilic species to accomplish the synthetic objectives. Other aspects of the project examine the critical structure-activity relationships of the superelectrophiles. These mechanistic studies (including theoretical calculations) will help to better understand the chemistry of the superelectrophiles. As a result of this project, the potential impact of superelectrophiles in biochemical transformations can also be established.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Douglas A. Klumpp of the Department of Chemistry and Biochemistry at Northern Illinois University. Professor Klumpp's research centers on the chemistry of highly reactive electrophiles. Electrophilic chemistry is of broad importance in biological processes, in the actions of medicines and drugs, and in facilitating the chemical conversions in the chemical industry. Successful completion of the proposed research will consequently have an impact in these areas of science, medicine, and industry.