The Texas Two-step Approach to Priviledged Chirons

德克萨斯州特权凯龙星的两步法

• 批准号: 0750193
• 负责人: Kevin Burgess
• 金额: $ 42.6万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0750193&HistoricalAwards=false
• 关键词: Texas; Two; step; Approach; Priviledged

The project focuses on the asymmetric hydrogenation of unfunctionalized alkenes. There are two specific aims. One is to use asymmetric hydrogenation of largely unfunctionalized alkenes to prepare widespread fragments in chiral, acyclic molecules and the other is to optimize and refine the optically active carbene oxazoline catalyst developed previously to facilitate enantioselective hydrogenation of a more diverse set of largely unfunctionalized alkenes. These studies will be applied to form all stereochemical permutations of difunctionalized chirons that correspond to some of the most fundamental building blocks in chiral, acyclic molecules.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Kevin Burgess in the Department of Chemistry at Texas A&M University. Professor Burgess will focus his work on the development of methodology for the asymmetric hydrogenation of unfunctionalized alkenes. A great range of genuinely useful chiral building blocks will be prepared. The work has the potential for broader impact in the pharmaceutical industry and the project serves as an excellent venue for the training of undergraduates, graduate students, and postdoctoral fellows.

该项目的重点是非官能化烯烃的不对称氢化。 有两个具体目标。 一个是使用不对称氢化的大部分未官能化的烯烃制备广泛的片段在手性，无环分子和其他是优化和完善的光学活性卡宾恶唑啉催化剂，以前开发的，以促进对映选择性氢化的一组更多样化的大部分未官能化的烯烃。 这些研究将应用于形成双官能化手性化合物的所有立体化学排列，这些手性化合物对应于手性非环状分子中一些最基本的结构单元。有了这个奖项，有机和大分子化学计划将支持德克萨斯州A M大学化学系Kevin Burgess博士的研究。 伯吉斯教授将专注于非官能化烯烃的不对称氢化方法的发展。 将制备大量真正有用的手性构建单元。 这项工作有可能在制药行业产生更广泛的影响，该项目是本科生，研究生和博士后研究员培训的绝佳场所。