Engineering of a microbial platform for the conversion of light energy into chemical and electrical energy

将光能转化为化学能和电能的微生物平台工程

• 批准号: 0756296
• 负责人: Claudia Schmidt-Dannert
• 金额: $ 75万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2013-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0756296&HistoricalAwards=false
• 关键词: Engineering; microbial; platform; conversion; light

Engineering of a Microbial Platform for the Conversion of Light Energy into Chemical and Electrical EnergyClaudia M Schmidt-Dannert University of Minnesota-Twin CitiesCBET-0756296Intellectual Merit Capture and conversion of abundant solar energy will be essential for the development of sustainable, future biotechnologies. Photosynthesis is used for the production of biofuels mostly via traditional agricultural or forestry production systems, although efforts are increasingly directed at developing microbial photosynthesis for biohydrogen production. However, light-energy could potentially also be used to drive desirable energy demanding metabolic processes or the generation of electricity in engineered cells. This can be achieved by either metabolically engineering photosynthetic microbial cells such that light-energy can be channeled into desired metabolic outputs or electricity; or by installing lightconverting photochemical reaction centers (RC's) from photoautotrophic organisms into cells that have desired and flexible metabolic capabilities and/or ability to generate electricity.Broader Impact: This project will explore mechanisms by which abundant light-energy can be utilized to drive metabolic processes and electricity generation in engineered microbial cells. As such this project will impact the field of microbial biochemistry and biotechnology. Findings may promote additional engineering efforts aimed at interfacing photosynthetic components with metabolic processes in microbial cells. This project will also provide interdisciplinary training in biochemistry, microbial and electrical engineering for two graduate students and a postdoctoral researcher. In addition, 2-4 undergraduate students are anticipated to participate at no additional costs. The Principal Investigators' laboratories have a strong track record of attracting female minority students to conduct directed research projects.

将光能转化为化学能和电能的微生物平台工程克劳迪娅·M·施密特-丹纳特明尼苏达大学双城分校CBET-0756296智力成果捕获和丰富太阳能的转换对于可持续的未来生物技术的发展至关重要。尽管人们越来越多地致力于开发微生物光合作用来生产生物氢，但光合作用主要通过传统的农业或林业生产系统用于生产生物燃料。然而，光能也有可能用于驱动需要能量的代谢过程或工程细胞中的发电。这可以通过对光合微生物细胞进行代谢改造来实现，以便将光能转化为所需的代谢输出或电力；或者通过将来自光自养生物的光转换光化学反应中心（RC）安装到具有所需且灵活的代谢能力和/或发电能力的细胞中。更广泛的影响：该项目将探索利用丰富的光能来驱动工程微生物细胞中的代谢过程和发电的机制。因此，该项目将影响微生物生物化学和生物技术领域。研究结果可能会促进更多的工程努力，旨在将光合成分与微生物细胞的代谢过程结合起来。 该项目还将为两名研究生和一名博士后研究员提供生物化学、微生物和电气工程方面的跨学科培训。此外，预计有 2-4 名本科生免费参加。首席研究员实验室在吸引少数民族女学生开展定向研究项目方面有着良好的记录。