Research Starter: Population Dynamics and Evolution of Emerging Viruses
研究启动器:种群动态和新兴病毒的进化
基本信息
- 批准号:0804039
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-08-01 至 2010-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
About five percent of the world's population died when the last major influenza pandemic swept the world in 1918. Yet our understanding of emerging infectious diseases has increased only superficially in the past century. Some viruses spread pandemically through populations, whereas others appear only briefly before disappearing. Theory indicates that a virus's ability to adapt to its new host is critical its emergence, and that its ability to adapt is partially a function of virus immigration into an evolving population. The proposed laboratory experiments test how immigration affects an emerging virus's ability to adapt, by manipulating the number of immigrants entering an experimental population. Contrary to intuition, if theory is correct, there may be a positive relationship between immigration and adaptation. This result would challenge conventional wisdom regarding local adaptation. This research will permit a better understanding of how viruses emerge, and potentially allow us to predict which ones are greater threats than others to host populations. The project has broader implications beyond the study of disease emergence. The PI is himself disabled, and as such provides a role model for other such individuals. The PI's institution has a large minority population, and the PI will integrate minority graduate, undergraduate and high school students into his research program.
上一次大规模流感大流行于1918年席卷全球时,约有5%的世界人口死亡。然而,在过去的世纪里,我们对新兴传染病的了解只是表面上的增加。有些病毒在人群中大规模传播,而另一些病毒在消失前只出现很短时间。理论表明,病毒适应新宿主的能力是其出现的关键,并且其适应能力部分是病毒迁移到进化种群中的功能。拟议中的实验室实验通过操纵进入实验人群的移民数量来测试移民如何影响新出现的病毒的适应能力。与直觉相反,如果理论是正确的,移民和适应之间可能存在正相关关系。这一结果将挑战关于当地适应的传统智慧。 这项研究将使我们能够更好地了解病毒是如何出现的,并可能使我们能够预测哪些病毒对宿主种群的威胁比其他病毒更大。该项目具有更广泛的意义,超出了疾病出现的研究。PI本身是残疾人,因此为其他此类个人提供了榜样。PI的机构有大量的少数民族人口,PI将少数民族研究生,本科生和高中生融入他的研究计划。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John Dennehy其他文献
Physical activity interventions among youth living in rural and remote areas: A systematic review.
农村和偏远地区青年的体育活动干预措施:系统评价。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:3.5
- 作者:
John Dennehy;Melainie Cameron;Tania M Phillips;Tracy Kolbe - 通讯作者:
Tracy Kolbe
John Dennehy的其他文献
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{{ truncateString('John Dennehy', 18)}}的其他基金
I-Corps: Passive in situ pathogen concentration device for wastewater-based epidemiology
I-Corps:用于废水流行病学的被动原位病原体浓缩装置
- 批准号:
2329731 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: HSI Implementation and Evaluation Project: Developing a Wastewater-based Epidemiology Student Training and Education Program at CUNY
合作研究:HSI 实施和评估项目:在纽约市立大学制定基于废水的流行病学学生培训和教育计划
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2318300 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
RAPID: Collaborative Research: Metapopulation Modeling to Develop Strategies to Reduce COVID-19 Transmission in Public Spaces
RAPID:协作研究:通过元群体建模制定减少公共场所 COVID-19 传播的策略
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2032634 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Standard Grant
CAREER: Population Dynamics and Evolutionary Ecology of Viral Emergence
职业:病毒出现的种群动态和进化生态学
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1148879 - 财政年份:2012
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0918199 - 财政年份:2009
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Minority Postdoctoral Research Fellowship for FY 2003
2003财年少数族裔博士后研究奖学金
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0310205 - 财政年份:2003
- 资助金额:
-- - 项目类别:
Fellowship Award
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