MRI: Acquisition of a Gemini R Ultra X-ray Diffractometer for Structural Biology and Chemistry

MRI：购买 Gemini R Ultra X 射线衍射仪用于结构生物学和化学

• 批准号: 0819686
• 负责人: Roger Rowlett
• 金额: $ 41.07万
• 依托单位: Colgate University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0819686&HistoricalAwards=false
• 关键词: MRI; Acquisition; Gemini; Ultra; ray

With this award from the Major Research Instrumentation program (MRI), Roger Rowlett and colleagues Anthony Chianese and G. Richard Geier III from Colgate University will acquire a single-crystal X-ray diffractometer (XRD) to support research in chemistry and biochemistry including the study of enzyme mechanisms and structure, organometallic catalysis, porphyrinic macrocycles as well as examination of the mechanism of bacterial carbonic anhydrase in E. coli. The instrumentation will also impact undergraduate research, training, and teaching at Colgate and regional undergraduate institutions. The technique of single-crystal X-ray crystallography allows accurate and precise determination of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of molecules relative to the neighboring molecules. These studies will have an impact in a number of areas ranging from synthetic chemistry to systems of biological interest.

凭借这项来自主要研究仪器项目（MRI）的奖励，来自高尔盖特大学的Roger Rowlett及其同事Anthony Chianese和G. Richard Geier III将获得一台单晶x射线衍射仪（XRD），以支持化学和生物化学的研究，包括酶的机制和结构、有机金属催化、卟啉大环的研究以及大肠杆菌中细菌碳酸酐酶的机制的研究。该仪器还将影响高露洁和地区本科院校的本科生研究、培训和教学。单晶x射线晶体学技术允许精确和精确地测定分子的完整三维结构，包括键的距离和角度，它提供了分子相对于邻近分子的空间排列的准确信息。这些研究将对从合成化学到生物系统等许多领域产生影响。