MRI: Acquisition of a Circular Dichroism Spectrophotometer

MRI：圆二色性分光光度计的获取

• 批准号: 0820845
• 负责人: Richard Sheardy
• 金额: --
• 依托单位: Texas Woman's University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0820845&HistoricalAwards=false
• 关键词: MRI; Acquisition; Circular; Dichroism; Spectrophotometer

The Department of Chemistry and Physics at Texas Woman's University will acquire a circular dichroism spectrophotometer with this award from the Major Research Instrumentation (MRI) program. Principal Investigator Sheardy will investigate the influence of sequence and environment of G-quadruplex nucleic acid secondary structures. The goals of co-PI Anderson's research are to understand the function and mechanism of human Glutathione Synthetase. The primary purpose of co-PI Britt's proposed research is to thermodynamically characterize the transition states and conformational changes of several non-denatured enzymes. A circular dichroism spectrophotometer will produce spectral data that provides information on molecular structure and especially the conformations of bio-molecules such as nucleic acids, proteins, enzymes and nucleic acids. The instrument will be used in research by graduate and undergraduate students. The theory and practice of circular dichroism spectroscopy will be incorporated into the undergraduate teaching curriculum. This training will prepare students to utilize this sophisticated technique in various careers, especially in chemical, biological and health related fields.

德克萨斯女子大学的化学和物理系将从主要研究仪器（MRI）计划中获得一个圆二色性分光光度计。 首席研究员Sheardy将研究G-四链体核酸二级结构的序列和环境的影响。合作PI安德森的研究目标是了解人类谷胱甘肽合成酶的功能和机制。 合作PI布里特的研究建议的主要目的是化学表征的过渡状态和构象变化的几个非变性酶。圆二色性分光光度计将产生光谱数据，其提供关于分子结构的信息，特别是生物分子如核酸、蛋白质、酶和核酸的构象。 该仪器将用于研究生和本科生的研究。 圆二色光谱的理论和实践将纳入本科教学课程。 这项培训将帮助学生在各种职业中利用这种复杂的技术，特别是在化学，生物和健康相关领域。