MRI: Acquisition of a Circular Dichroism Spectrophotometer

得克萨斯女子大学化学和物理系将从主要研究仪器(MRI)计划获得这一奖项的圆二色分光光度计。首席研究员谢尔迪将研究G-四链核酸二级结构的序列和环境的影响。皮安德森的研究目的是了解人类谷胱甘肽合成酶的功能和机制。皮布里特联合提出的研究的主要目的是从热力学上表征几种非变性酶的过渡态和构象变化。圆二色分光光度计将产生光谱数据，提供关于分子结构的信息，特别是生物分子的构象信息，如核酸、蛋白质、酶和核酸。该仪器将用于研究生和本科生的研究。将圆二色光谱的理论与实践纳入本科教学课程。这项培训将为学生在各种职业中使用这项复杂的技术做好准备，特别是在化学、生物和健康相关领域。

The Department of Chemistry and Physics at Texas Woman's University will acquire a circular dichroism spectrophotometer with this award from the Major Research Instrumentation (MRI) program. Principal Investigator Sheardy will investigate the influence of sequence and environment of G-quadruplex nucleic acid secondary structures. The goals of co-PI Anderson's research are to understand the function and mechanism of human Glutathione Synthetase. The primary purpose of co-PI Britt's proposed research is to thermodynamically characterize the transition states and conformational changes of several non-denatured enzymes. A circular dichroism spectrophotometer will produce spectral data that provides information on molecular structure and especially the conformations of bio-molecules such as nucleic acids, proteins, enzymes and nucleic acids. The instrument will be used in research by graduate and undergraduate students. The theory and practice of circular dichroism spectroscopy will be incorporated into the undergraduate teaching curriculum. This training will prepare students to utilize this sophisticated technique in various careers, especially in chemical, biological and health related fields.