Acquisition of Automated Genetic Analyzer for Interdisciplinary Research, Teaching and Training in Molecular Phylogenetics, Biology, and Bioinformatics in an Undergraduate College

购置自动遗传分析仪，用于本科院校分子系统发育学、生物学和生物信息学的跨学科研究、教学和培训

• 批准号: 0821832
• 负责人: Aaron Best
• 金额: --
• 依托单位: Hope College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0821832&HistoricalAwards=false
• 关键词: Acquisition; Automated; Genetic; Analyzer; Interdisciplinary

A grant has been awarded to Hope College to purchase an automated genetic analyzer for research and training in evolutionary biology, microbiology, molecular biology, and bioinformatics. The instrument, which will be used by both faculty and students, will significantly impact multiple areas of research and teaching. First, it will be used to collect DNA sequence data for evolutionary studies of the pineapple family, whose species have been under increasing risk of extinction due to extensive habitat loss. Second, it will be used to examine genome evolution in the primitive eukaryote Giardia lamblia, the parasite that causes Giardiasis. Third, the instrument will be used to learn more about how genes are regulated by fatty acids through a study in yeast. Lastly, it will be used in a comparative analysis of virus genomes as part of the HHMI-funded Phage Genomics Research InitiativeThe automated genetic analyzer will have broad impacts by helping to train Hope College undergraduate students and NSF-REU students in modern scientific techniques, thereby encouraging them to pursue careers in science. It will strengthen Hope?s HHMI-funded program in phage genomics, which is an initiative targeted at retaining outstanding freshmen in science, and it will be used to foster faculty-student collaborative research in plant evolution, microbial genomics, cell biology, and biochemistry. With its service in research laboratories as well as in several different classes, the instrument will provide at least 100 undergraduate students per year with hands-on experience in sample preparation, state-of-the-art DNA sequencing, and data analysis and interpretation.

霍普学院获得了一笔赠款，用于购买一台自动遗传分析仪，用于进化生物学、微生物学、分子生物学和生物信息学的研究和培训。该仪器将由教职员工和学生使用，将对多个研究和教学领域产生重大影响。首先，它将被用于收集DNA序列数据，用于菠萝科的进化研究，由于广泛的栖息地丧失，菠萝科的物种面临着越来越大的灭绝风险。其次，它将被用于研究原始真核生物兰氏贾第鞭毛虫的基因组进化，兰氏贾第鞭毛虫是导致贾第虫病的寄生虫。第三，通过在酵母中的研究，该仪器将被用来更多地了解脂肪酸是如何调控基因的。最后，它将用于病毒基因组的比较分析，作为HHMI资助的噬菌体基因组研究计划的一部分。自动化基因分析仪将产生广泛的影响，帮助培训霍普学院本科生和NSF-REU学生掌握现代科学技术，从而鼓励他们从事科学事业。它将加强希望？S HHMI资助的噬菌体基因组学计划，该计划旨在留住优秀的理科新生，并将用于促进在植物进化、微生物基因组学、细胞生物学和生物化学方面的师生合作研究。通过在研究实验室和几个不同的班级提供服务，该仪器每年将为至少100名本科生提供样品准备、最先进的DNA测序以及数据分析和解释方面的实践经验。