Collaborative Research: Scaling Laws for NanoFET Biosensors

合作研究：纳米场效应晶体管生物传感器的标度律本研究的目的是对纳米场效应晶体管生物传感器的性能如何在不同的物理条件下取决于器件的几何尺寸进行基本的了解。该方法是通过使用随机电阻网络模型来数值研究在各种物理条件下的器件标度行为，并通过使用Si基器件作为模型系统来实验测试在不同场效应强度下的这些标度律。这项研究的结果将回答从根本上有趣的和技术上重要的问题，是否和如何场效应生物传感器的灵敏度和检测限取决于它们的几何尺寸和相关的物理参数。该项目是变革性的，因为场效应生物传感器的比例定律作为关键设计准则，将使灵敏度和检测限能够根据目标分析物浓度进行定制，并使设备设计具有超低检测限。更广泛的影响：超灵敏的生物传感器可以找到从食品安全，国土安全到人类医疗保健疾病诊断的各种应用。研究生和本科生将在设备和计算物理，半导体纳米结构制造和表征，以及表面和界面生物化学这个跨学科的项目进行培训。将作出特别努力，招收女生和代表人数不足的少数民族学生参加。该项目的研究发现将纳入主要研究人员开发的课程。外展活动包括参观学校，培训高中生，并参与NSF GK-12计划。

Collaborative Research: Scaling Laws for NanoFET BiosensorsThe objective of this research is to develop fundamental understanding on how the performance of nanoscale field effect transistor biosensors depends on device geometrical sizes at different physical conditions. The approach is to numerically investigate device scaling behaviors at various physical conditions by using a random resistor network model and experimentally test these scaling laws at different field effect strengths by using Si-based devices as a model system.Intellectual Merit: The outcome of this research will answer the fundamentally intriguing and technologically important question on whether and how the sensitivity and detection limits of field effect biosensors depend on their geometrical dimensions and relevant physical parameters. The project is transformative in terms that scaling laws for field effect biosensors as critical design guidelines will enable tailoring the sensitivity and detection limits in accordance with target analyte concentrations, and enable design of devices with ultra-low detection limits. Broader Impacts: Ultra-sensitive biosensors can find various applications from food safety, homeland security to disease diagnostics for human health care. Graduate and undergraduate students will be trained in this interdisciplinary project on device and computational physics, semiconductor nanostructure fabrication and characterization, and surface and interface biochemistry. Special efforts will be made to recruit female and underrepresented minority students for participation. Research discoveries from this project will be incorporated into the courses developed by the principle investigators. Outreach activities include school visits, training of high school senior students, and participation of NSF GK-12 Program.