SGER: FABRICATION AND EXPERIMENTAL TESTING OF MICROFLUIDIC DEVICES WITH INTEGRATED ELECTRODES FOR THE MANIPULATION OF BIOLOGICAL AND NON-BIOLOGICAL ANALYTES

这项研究将涉及微流控系统的制造以及悬浮液中分析物的实验测试。微生物、碳纳米管、干细胞和细菌(如枯草杆菌(炭疽))将使用集成电极的微流控设备进行操作。智力优势：这里提出的研究将涉及开发一种微流控系统，该系统将能够使用电流体动力学技术在细胞水平上分析生物颗粒。这包括(1)快速分离、检测和分析单个细胞的能力将在分析化学的前沿领域取得突破；(2)快速检测和识别炭疽病等生物制剂的能力将为国家安全和国防带来重大好处；以及(3)干细胞分离和分析的能力可以在癌症和阿尔茨海默病的治疗方面取得重大进展。更广泛的影响：这种分离技术的发展将为发现新的生物体打开大门，并在生物战剂检测领域取得重大突破。通过去除这些自然资源中的污染物颗粒、细菌和病毒，空气和水资源的质量将得到改善。这项技术将在生物医学领域带来细胞分选和生物悬浮液中杂质去除的改进。这将导致对疾病的理解的进步。此外，这项技术还将在国防、环保和医学领域带来重大进步。作为教育计划的一部分，密歇根大学迈耶霍夫项目的有才华、代表性不足的少数群体以及国内学生将成为这项研究的目标。迈耶霍夫项目是吸引和留住少数族裔学生的全国典范，这些学生将攻读数学或科学方面的高级学位，重点是帮助代表不足的群体。

CBET-0827242BennettThis research will involve the fabrication of microfluidic systems as well as the experimental testing of analytes in suspension. Microscopic organisms, carbon nanotubes, stem cells, and bacteria such as bacillus subtilis (anthrax) will be manipulated using microfluidic devices with integrated electrodes.Intellectual Merit: The research presented here will involve developing a microfluidic system that will be able to analyze biological particles on the cellular level using electrohydrodynamic techniques. This includes (1) The ability to rapidly isolate, detect, and analyze single cells will provide breakthroughs on the frontiers of analytical chemistry; (2) The ability to rapidly detect and identify biowarfare agents such as anthrax will provide significant benefits to national security and defense; and (3) The ability to separate and analyze stem cells can lead to significant advances towards cures for cancer and Alzheimer's disease. Broader Impact:The development of such separation techniques will open the door for the discovery of new organisms and provide significant breakthroughs in the area of biological warfare agent detection. The quality of air and water resources will be improved by removing pollutant particles, bacteria, and viruses from these natural resources. This technology will lead to improvement in biomedical fields for cell sorting and removing impurities from biological suspensions. This will lead to advances in understanding of diseases. In addition, this technology will also provide significant advances in the areas of defense, environmental protection, and medicine. As part of the educational plan, talented underrepresented minority groups from the Meyerhoff Program at UMBC as well as domestic students will be targeted for this research. The Meyerhoff Program is a national model for attracting and retaining, primarily minority students, who will pursue advanced degrees in mathematics or science with an emphasis in helping underrepresented groups.