CRCNS data sharing: Comparative Neuromics of Gastropod Molluscs

该奖项支持计算神经科学数据的准备和共享，作为CRCNS计划的一个新组成部分，旨在促进计算神经科学和相关领域的快速创新进步。通过多个实验室的合作，本项目结合了几个重要的腹足动物模型系统的神经系统知识，包括Aplysia、Clione、Helisoma、Helix （Cantareus）、Hermissenda、Limax、lynaea、Melibe、Pleurobranchaea和Tritonia，努力为未来腹足动物的比较神经学奠定基础。就像比较基因组学使研究人员能够从基因组的相似性和差异性来理解生物体的进化和发展一样，比较神经学，即神经元及其跨物种连接的比较，为增加我们对神经系统结构和功能的理解提供了前所未有的机会。腹足类软体动物特别适合进行神经学分析，因为它们具有可单独识别的大型神经元，并且对从陆地和水生肺门动物到海洋蛇门动物的研究已经进行了40多年，这些物种生活在不同的生态位中。该项目将把关于腹足动物神经元和神经回路的已发表知识整合到一个可搜索的、可扩展的知识库中，以一种可以与其他知识库和主要数据源联合的格式呈现。该项目将建立在目前可用的基于网络的工具上，并与其他相关工作协调，如NeuronBank、开放生物医学本体，以及正在为生物医学信息学研究网络和神经科学信息框架开发的神经科学特定本体。gastropod用户社区参与提供信息来源和测试项目结果，以确保表示的准确性和格式的可用性。随着基因组工具通过apilsia基因组计划和其他倡议变得可用，巩固大量积累的腹足类神经系统知识对于扩大这些模式生物的使用至关重要。该项目将作为联合其他数据库的基础，包括神经元形态学、神经元和神经回路计算模拟以及信号转导途径。它还将为拥有更多不同神经系统的大型研究团体提供概念证明。

This award supports the preparation and sharing of computational neuroscience data as part of a new component of the CRCNS program aimed at catalyzing rapid and innovative advances in computational neuroscience and related fields. Through a collaborative effort of many laboratories, this project combines knowledge about the nervous systems of several important gastropod model systems, including Aplysia, Clione, Helisoma, Helix (Cantareus), Hermissenda, Limax, Lymnaea, Melibe, Pleurobranchaea, and Tritonia, in an effort to lay the foundation for future comparative neuromics in gastropods.Just as comparative genomics has enabled researchers to understand the evolution and development of organisms in terms of similarities and differences in their genomes, comparative neuromics, the comparison of neurons and their connections across species, offers unprecedented opportunities to increase our understanding of nervous system structure and function. Gastropod molluscs are uniquely suited for neuromic analysis because they have large individually identifiable neurons and work has proceeded for over four decades on species ranging from terrestrial and aquatic pulmonates to marine opisthobranchs, which inhabit diverse ecological niches. This project will consolidate the published knowledge about gastropod neurons and neural circuits into a searchable, extensible knowledge base, to be rendered in a format that can be federated with other knowledge repositories and primary data sources. This project will build on currently available web-based tools and coordinate with other related efforts, such as NeuronBank, Open Biomedical Ontologies, and neuroscience-specific ontologies being developed for the Biomedical Informatics Research Network and the Neuroscience Information Framework. The gastropod user community is involved in providing sources of information and testing the outcome of the project to assure the accuracy of the representation and the usability of the format. Consolidating the vast amount of accumulated knowledge about gastropod nervous systems is essential for the expanded use of these model organisms as genomic tools become available through the Aplysia genome project and other initiatives. This project will serve as a basis for federating other databases including neuronal morphology, neuronal and neural circuit computational simulations, and signal transduction pathways. It will also serve as a proof of concept for larger research communities with more disparate nervous systems.