SGER: Developing a Catalytic Aldehyde Olefination Reaction

SGER：开发催化醛烯化反应

• 批准号: 0829263
• 负责人: Yun-Ming Lin
• 金额: --
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2010-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0829263&HistoricalAwards=false
• 关键词: SGER; Developing; Catalytic; Aldehyde; Olefination

This SGER project will explore the substrate scopes of the newly discovered catalytic, highly stereoselective aldehyde olefination reaction. While transforming an aldehyde carbonyl group into a C-C double bond is a ubiquitous organic reaction, the development of a catalytic aldehyde olefination reaction without employing either Ph3P or Bu3As is significantly lacking. Without employing the phosphine-based and/or phosphonate-based reagents, the new catalytic aldehyde olefination reaction holds great promises to become an environmentally more friendly reaction. Studies to further expand the substrate scopes of the catalytic aldehyde olefination reaction will be undertaken. Design and screening of additional ligands with different metals will be carried out to identify new, and potentially more active catalysts. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Yun-Ming Lin of the Department of Chemistry at the University of Toledo. Professor Yun-Ming Lin 's research efforts focus on the development of new catalytic methods for constructing C-C and carbon-heteroatom bonds. Such chemistry will contribute to environmentally benign methods for chemical synthesis because less chemical wastes will be produced. Successful development of the catalytic methods will have a positive impact on synthesis in the pharmaceutical and agricultural industries.

这个SGER项目将探索新发现的催化，高度立体选择性的醛烯化反应的底物范围。 虽然将醛羰基转化为C-C双键是普遍存在的有机反应，但是显著缺乏不使用Ph 3 P或Bu 3As的催化醛烯化反应的开发。 在不使用膦基和/或膦酸酯基试剂的情况下，新的催化醛烯化反应很有希望成为环境更友好的反应。 进一步扩大醛烯烃化催化反应的底物范围的研究将进行。 将进行具有不同金属的额外配体的设计和筛选，以确定新的和潜在的更活性的催化剂。 有了这个奖项，有机和高分子化学计划正在支持托莱多大学化学系林云明教授的研究。 林云明教授的研究工作集中于开发新的催化方法来构建碳-碳和碳-杂原子键。 这种化学方法将有助于采用无害环境的化学合成方法，因为将产生较少的化学废物。 催化方法的成功开发将对制药和农业工业的合成产生积极影响。