Developing Catalytic Nanogels as General Purpose Glycosidases

开发催化纳米凝胶作为通用糖苷酶

基本信息

  • 批准号:
    1854304
  • 负责人:
  • 金额:
    $ 48.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-06-01 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

Developing new routes to transform readily available and renewable resources into useful materials is one of the grand challenges of the 21st century chemistry. The design of catalysts that mimic the enzymes used by nature is a promising way to transform readily available starting materials such as plant cellulose. In this project, Professor Susanne Striegler of the University of Arkansas is developing fundamental understanding of enzyme-like catalysts and exploiting the synergy between their structure and function. This basic research is beneficial to our society as new avenues toward fine chemicals from bio-renewable resources grow in importance. Dr. Striegler is actively engaged in outreach activities to encourage middle and high school students in STEM (science, technology, engineering, and mathematics) disciplines and in combination with German language skill development. Encouraging students to strengthen their German language skills and STEM education prepares them to engage others at an international level and to study and work abroad.With funding from the Chemical Catalysis and Macromolecular, Supramolecular and Nanochemistry Programs of the Chemistry Division, Dr. Striegler of the University of Arkansas is developing biomimetic macromolecular, nanogel catalysts and elaborating the synergy between catalysis-supporting matrix effects and the catalytic function of transition metal complexes. The resulting catalysts may find applications ranging from new antimicrobial agents to biofuel production from non-activated oligosaccharides. Structure-activity relationship studies are being used to elaborate transition state-stabilizing interactions between non-activated saccharides and binuclear copper(II) complexes. The studies utilize kinetic analyses in combination with a computational approach to reveal binding sites of the saccharides, and energies and geometries of sugar-metal complex assemblies. The fundamental and basic studies are projected to maximize the catalytic potency of nanogels and open new research frontiers in biomimetic catalysis. Dr. Striegler is actively engaged in outreach programs focusing on student recruitment into the STEM fields by connecting German speaking local middle and high-school students and their teachers to the training and career opportunities in the STEM field.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
开发新的途径将易得的和可再生的资源转化为有用的材料是21世纪世纪化学的重大挑战之一。模拟自然界使用的酶的催化剂的设计是一种有前途的方法来转化容易获得的起始材料,如植物纤维素。在这个项目中,阿肯色州大学的Susanne Striegler教授正在发展对酶样催化剂的基本理解,并利用它们的结构和功能之间的协同作用。这项基础研究对我们的社会是有益的,因为从生物可再生资源中获得精细化学品的新途径越来越重要。Striegler博士积极参与外展活动,以鼓励初中和高中学生在STEM(科学,技术,工程和数学)学科,并结合德语技能的发展。鼓励学生加强他们的德语技能和STEM教育,为他们在国际层面上参与他人以及在国外学习和工作做好准备。在化学系化学催化和大分子,超分子和纳米化学项目的资助下,阿肯色州大学的Striegler博士正在开发仿生大分子,纳米凝胶催化剂,并阐述了催化剂之间的协同作用,支持矩阵效应和过渡金属配合物的催化功能。由此产生的催化剂可能会发现应用范围从新的抗菌剂到非活化低聚糖的生物燃料生产。结构-活性关系的研究正在被用来阐述非活化的双核铜(II)配合物之间的过渡态稳定的相互作用。这些研究利用动力学分析结合计算方法来揭示糖的结合位点,以及糖-金属络合物组装体的能量和几何形状。基础和基础研究预计将最大限度地发挥纳米凝胶的催化潜力,并在仿生催化方面开辟新的研究前沿。Striegler博士积极致力于STEM领域的学生招募推广计划,将德语当地的初中和高中学生及其教师与STEM领域的培训和职业机会联系起来。该奖项反映了NSF的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Polarity and Critical Micelle Concentration of Surfactants Support the Catalytic Efficiency of Nanogels during Glycoside Hydrolyses
  • DOI:
    10.1021/acscatal.2c01432
  • 发表时间:
    2022-07
  • 期刊:
  • 影响因子:
    12.9
  • 作者:
    B. Sharma;S. Striegler
  • 通讯作者:
    B. Sharma;S. Striegler
Nanogel Catalysts for the Hydrolysis of Underivatized Disaccharides Identified by a Fast Screening Assay
通过快速筛选测定鉴定用于水解未衍生化二糖的纳米凝胶催化剂
  • DOI:
    10.1021/acscatal.2c05575
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    12.9
  • 作者:
    Sharma, Babloo;Striegler, Susanne
  • 通讯作者:
    Striegler, Susanne
Solvent-controlled synthesis of bulky and polar-bulky galactonoamidines
  • DOI:
    10.1016/j.carres.2022.108520
  • 发表时间:
    2022-02-19
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Striegler,Susanne;Orizu,Ifedi
  • 通讯作者:
    Orizu,Ifedi
Characterizing the Solvent‐Induced Inversion of Colloidal Aggregation During Electrophoretic Deposition
电泳沉积过程中溶剂诱导胶体聚集反转的表征
  • DOI:
    10.1002/admi.202201779
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    5.4
  • 作者:
    DeMoulpied, Justin R.;Killenbeck, Jessica A.;Schichtl, Zebulon G.;Sharma, Babloo;Striegler, Susanne;Coridan, Robert H.
  • 通讯作者:
    Coridan, Robert H.
Microgel-Catalyzed Hydrolysis of Nonactivated Disaccharides
  • DOI:
    10.1021/acscatal.0c03401
  • 发表时间:
    2020-12-18
  • 期刊:
  • 影响因子:
    12.9
  • 作者:
    Striegler, Susanne;Sharma, Babloo;Orizu, Ifedi
  • 通讯作者:
    Orizu, Ifedi
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Susanne Striegler其他文献

<em>N</em>-Benzylgalactonoamidines as potent β-galactosidase inhibitors
  • DOI:
    10.1016/j.tet.2011.10.048
  • 发表时间:
    2012-01-07
  • 期刊:
  • 影响因子:
  • 作者:
    Rami Kanso;Elizabeth A. Yancey;Susanne Striegler
  • 通讯作者:
    Susanne Striegler

Susanne Striegler的其他文献

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{{ truncateString('Susanne Striegler', 18)}}的其他基金

I-Corps: Antimicrobial Microgels for Air Purification
I-Corps:用于空气净化的抗菌微凝胶
  • 批准号:
    1946566
  • 财政年份:
    2019
  • 资助金额:
    $ 48.5万
  • 项目类别:
    Standard Grant
Microgel catalysts mimicking glycosidases
模拟糖苷酶的微凝胶催化剂
  • 批准号:
    1305543
  • 财政年份:
    2013
  • 资助金额:
    $ 48.5万
  • 项目类别:
    Standard Grant
CAREER: Macromolecular glycosidase mimics
职业:大分子糖苷酶模拟物
  • 批准号:
    1244755
  • 财政年份:
    2012
  • 资助金额:
    $ 48.5万
  • 项目类别:
    Standard Grant
CAREER: Macromolecular glycosidase mimics
职业:大分子糖苷酶模拟物
  • 批准号:
    0746635
  • 财政年份:
    2008
  • 资助金额:
    $ 48.5万
  • 项目类别:
    Standard Grant

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  • 批准号:
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    2024
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用于催化水净化的工程氧化还原聚合物
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难以混合的塑料的催化化学分选
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开发用于增强催化氨合成的原位氨捕获
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用于受控催化二氮功能化的早期金属双金属平台
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