Regulation and function of the Hox gene Ultrabithorax in the late embryonic central nervous system of Drosophila

Hox基因Ultrabithorax在果蝇胚胎晚期中枢神经系统中的调控和功能

• 批准号: 190057232
• 负责人: Dr. Ana Rogulja-Ortmann
• 金额: --
• 依托单位: Centre for Organismal Studies (COS)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/190057232?language=en
• 关键词: Regulation; function; Hox; gene; Ultrabithorax

The central nervous system represents the organ with the highest degree of complexity and cell diversity, as here diverse regional requirements for control of locomotion, feeding, respiration and reproduction need to be fulfilled. Understanding how this morphological and functional diversity arises during development is one of the fundamental challenges in biology. Homeotic genes encode one important class of transcription factors that regulate cell diversity along the anterior-posterior body axis. However, molecular mechanisms regulating homeotic gene expression in the nervous system, and the functions that these genes exert during development of the nervous system are largely unknown. The fruitfly Drosophila melanogaster is a widely used model organism for research in developmental biology. In the proposed project, regulation and function of the homeotic gene Ultrabithorax in the Drosophila embryonic central nervous system development will be investigated. The differences between the most important variants of the Ultrabithorax protein will be examined, looking both at how the different variants are generated and at the functional differences between them.

中枢神经系统是最复杂和细胞多样性最高的器官，因为在这里需要满足控制运动、摄食、呼吸和繁殖的各种区域需求。了解这种形态和功能多样性是如何在发育过程中产生的，是生物学的基本挑战之一。同卵异体基因编码一类重要的转录因子，这些转录因子沿着身体的前后轴调节细胞的多样性。然而，调控神经系统同型基因表达的分子机制以及这些基因在神经系统发育过程中发挥的功能在很大程度上是未知的。黑腹果蝇（Drosophila melanogaster）是一种广泛应用于发育生物学研究的模式生物。本课题将研究同源基因Ultrabithorax在果蝇胚胎中枢神经系统发育中的调控和功能。Ultrabithorax蛋白最重要的变体之间的差异将被检查，看看不同的变体是如何产生的，以及它们之间的功能差异。